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Two-dimensional crystallization of biological macromolecules
KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Structural Biotechnology. Karolinska Institutet,.ORCID iD: 0000-0002-3220-9402
2009 (English)In: Molecules: Nucleation, Aggregation and Crystallization: Beyond Medical and Other Implications, World Scientific Publishing Co. , 2009, 95-111 p.Chapter in book (Other academic)
Abstract [en]

Biological macromolecules can be arranged periodically in single layers as twodimensional (2D) crystals. This enables crystallographic structure analysis using transmission electron microscopy. Periodic repeat of a large number of unit cells contributes to significant information in images or diffraction patterns from unstained specimens. Structural details at a resolution of a few Ångströms in all directions can be obtained. Such three-dimensional maps are used for building atomic models. The techniques have been used to determine structure and function relationships for membrane proteins. The dense packing obtained in 2D crystals can also be used for constructing devices at the molecular level.

Place, publisher, year, edition, pages
World Scientific Publishing Co. , 2009. 95-111 p.
Keyword [en]
2D crystallization, Crystals, Membrane proteins
National Category
Chemical Sciences
URN: urn:nbn:se:kth:diva-195571DOI: 10.1142/9789812832665_0006ScopusID: 2-s2.0-84969722159ISBN: 9789812832665OAI: diva2:1048419

QC 20161121

Available from: 2016-11-21 Created: 2016-11-03 Last updated: 2016-11-21Bibliographically approved

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