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Essential Oils from Ugandan Medicinal Plants: In Vitro Cytotoxicity and Effects on IL-1 beta-Induced Proinflammatory Mediators by Human Gingival Fibroblasts
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2016 (English)In: Evidence-based Complementary and Alternative Medicine, ISSN 1741-427X, E-ISSN 1741-4288, 5357689Article in journal (Refereed) Published
Abstract [en]

The study investigated cytotoxicity of essential oils from four medicinal plants (Bidens pilosa, Ocimum gratissimum, Cymbopogon nardus, and Zanthoxylum chalybeum) on human gingival fibroblasts and their effects on proinflammatory mediators' secretion. Cytotoxicity of essential oils was investigated using 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide assay. Effects of essential oils at subcytotoxicity concentrations on interleukin-(IL-) 6, IL-8, and prostaglandin E-2 (PGE(2)) secretions by gingival fibroblasts treated with IL-1 beta (300 pg/mL) were evaluated by ELISA and EIA. IC50 values of the essential oils ranged from 26 mu g/mL to 50 mu g/mL. Baseline and IL-1 beta-induced secretion of PGE(2) was inhibited by treatment with essential oil from O. gratissimum. Essential oils from B. pilosa and C. nardus had synergistic effects with IL-1 beta on PGE(2) seceretion. In conclusion, the study suggests that essential oil from O. gratissimum decreases gingival fibroblasts secretion of PGE(2), while essential oils from B. pilosa and C. nardus increase PGE(2) secretion. Essential oil from Z. chalybeum was the most cytotoxic, while oil from C. nardus was the least cytotoxic. Although the clinical significance of these findings remains to be determined, it may be suggested that essential oil from O. gratissimum, applied at subcytotoxicity concentrations, could reduce the participation of gingival fibroblasts in the gingival inflammation and tissue destruction associated with periodontitis.

Place, publisher, year, edition, pages
Hindawi Publishing Corporation, 2016. 5357689
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:kth:diva-196648DOI: 10.1155/2016/5357689ISI: 000386272600001ScopusID: 2-s2.0-84994048616OAI: oai:DiVA.org:kth-196648DiVA: diva2:1049108
Funder
Sida - Swedish International Development Cooperation Agency, 75007369
Note

QC 20161123

Available from: 2016-11-23 Created: 2016-11-17 Last updated: 2016-11-23Bibliographically approved

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CiteExportLink to record
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