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Synthetic microfluidic paper allows controlled receptor positioning and improved readout signal intensity in lateral flow assays
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.ORCID iD: 0000-0001-8531-5607
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
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2015 (English)In: MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Chemical and Biological Microsystems Society , 2015, 284-286 p.Conference paper (Refereed)
Abstract [en]

Synthetic Microfluidic Paper consists of slanted and interlocked polymer micropillars and can be used as a porous substrate in microfluidics and lateral flow assays. We here demonstrate single step manufacturing of multiple Synthetic Microfluidic Paper densities in the same device, and passive alignment of liquid spots in denser substrate regions, regardless of spotting position, allowing increased control of receptor positioning for lateral flow assays. We further demonstrate that the transparency of Synthetic Microfluidic Paper allows increasing readout signal intensity with increasing substrate thickness, to a value 3 times larger compared to nitrocellulose substrates.

Place, publisher, year, edition, pages
Chemical and Biological Microsystems Society , 2015. 284-286 p.
Keyword [en]
Lab on Chip, Lateral flow assay, Microfluidics, Micropillar array, OSTE, Paper microfluidics, Receptor spotting, Assays, Paper, Substrates, Micropillar arrays
National Category
Nano Technology
Identifiers
URN: urn:nbn:se:kth:diva-194654ScopusID: 2-s2.0-84983247377ISBN: 9780979806483OAI: oai:DiVA.org:kth-194654DiVA: diva2:1050541
Conference
19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015, 25 October 2015 through 29 October 2015
Note

QC 20161129

Available from: 2016-11-29 Created: 2016-10-31 Last updated: 2016-11-29Bibliographically approved

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Hansson, JonasQuelennec, AuroreYasuga, HirokiHaraldsson, TommyVan Der Wijngaart, Wouter
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