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Slipdisc: A versatile sample preparation platform
KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology.
KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology.ORCID iD: 0000-0001-5199-0663
KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology.
KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology.
2015 (English)In: MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Chemical and Biological Microsystems Society , 2015, 1256-1258 p.Conference paper (Refereed)
Abstract [en]

We present "SlipDisc", a versatile sample preparation platform based on slipchip1 technology. The SlipDisc platform uses polycarbonate CDs and laser cut PSA instead of glass and a hand-winded mechanical clock mechanism to precisely manipulate minute amount of liquid. The innovative hand-winded mechanical "clockwork" that enables sample processing from one spot to another with defined precision. As a prof of principle of bioassay, we show HRP enzyme reacting with TMB substrate and a multilayer architecture used in manipulation of magnetic beads through an immiscible oil phase. Our long-term goal is to develop a sample-in-result-out multi-parametric bioanalytical SlipDisc platform specifically designed to need the needs at resource-limited settings for point of care molecular diagnostics.

Place, publisher, year, edition, pages
Chemical and Biological Microsystems Society , 2015. 1256-1258 p.
Keyword [en]
Clockwork, Resource limited settings, Sample preparation, Slipchip, Slipdisc, Long-term goals, Molecular diagnostics, Multi-layer architectures, Sample processing, Bioassay
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:kth:diva-194678ScopusID: 2-s2.0-84983268382ISBN: 9780979806483 (print)OAI: oai:DiVA.org:kth-194678DiVA: diva2:1050574
Conference
19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015, 25 October 2015 through 29 October 2015
Note

QC 20161129

Available from: 2016-11-29 Created: 2016-10-31 Last updated: 2016-11-29Bibliographically approved

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Citation style
  • apa
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