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Slipdisc: A versatile sample preparation platform
KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology.
KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology.
KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology.
KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology.
2015 (English)In: MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Chemical and Biological Microsystems Society , 2015, 1256-1258 p.Conference paper (Refereed)
Abstract [en]

We present "SlipDisc", a versatile sample preparation platform based on slipchip1 technology. The SlipDisc platform uses polycarbonate CDs and laser cut PSA instead of glass and a hand-winded mechanical clock mechanism to precisely manipulate minute amount of liquid. The innovative hand-winded mechanical "clockwork" that enables sample processing from one spot to another with defined precision. As a prof of principle of bioassay, we show HRP enzyme reacting with TMB substrate and a multilayer architecture used in manipulation of magnetic beads through an immiscible oil phase. Our long-term goal is to develop a sample-in-result-out multi-parametric bioanalytical SlipDisc platform specifically designed to need the needs at resource-limited settings for point of care molecular diagnostics.

Place, publisher, year, edition, pages
Chemical and Biological Microsystems Society , 2015. 1256-1258 p.
Keyword [en]
Clockwork, Resource limited settings, Sample preparation, Slipchip, Slipdisc, Long-term goals, Molecular diagnostics, Multi-layer architectures, Sample processing, Bioassay
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:kth:diva-194678ScopusID: 2-s2.0-84983268382ISBN: 9780979806483OAI: oai:DiVA.org:kth-194678DiVA: diva2:1050574
Conference
19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015, 25 October 2015 through 29 October 2015
Note

QC 20161129

Available from: 2016-11-29 Created: 2016-10-31 Last updated: 2016-11-29Bibliographically approved

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