Acoustic focusing of microparticles in two-phase systems - Towards cell enrichment or medium exchange in droplets
2015 (English)In: MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Chemical and Biological Microsystems Society , 2015, p. 1026-1028Conference paper, Published paper (Refereed)
Abstract [en]
We present a method to first laterally position microparticles inside droplets by acoustic forces and then split the droplet into three daughter droplets to achieve a 2+fold enrichment of microparticles inside the center droplet. We show that acoustic forces can be applied to both manipulate polystyrene beads (5 μm) and red blood cells inside droplets. The presented technology opens up for development of droplet operations used for medium exchange and particle concentration in droplet-based cell assays.
Place, publisher, year, edition, pages
Chemical and Biological Microsystems Society , 2015. p. 1026-1028
Keywords [en]
Droplet microfluidics, Integrated acoustics, Ultrasound, Ultrasonics, Acoustic focusing, Acoustic forces, Daughter droplets, Fold enrichments, Particle concentrations, Polystyrene beads, Two phase systems, Drops
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:kth:diva-194653Scopus ID: 2-s2.0-84983266550ISBN: 9780979806483 (print)OAI: oai:DiVA.org:kth-194653DiVA, id: diva2:1050587
Conference
19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015, 25 October 2015 through 29 October 2015
Note
Funding Details: Swedish Research Council
QC 20161129
2016-11-292016-10-312024-03-18Bibliographically approved