Acoustic focusing of microparticles in two-phase systems - Towards cell enrichment or medium exchange in droplets
2015 (English)In: MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Chemical and Biological Microsystems Society , 2015, 1026-1028 p.Conference paper (Refereed)
We present a method to first laterally position microparticles inside droplets by acoustic forces and then split the droplet into three daughter droplets to achieve a 2+fold enrichment of microparticles inside the center droplet. We show that acoustic forces can be applied to both manipulate polystyrene beads (5 μm) and red blood cells inside droplets. The presented technology opens up for development of droplet operations used for medium exchange and particle concentration in droplet-based cell assays.
Place, publisher, year, edition, pages
Chemical and Biological Microsystems Society , 2015. 1026-1028 p.
Droplet microfluidics, Integrated acoustics, Ultrasound, Ultrasonics, Acoustic focusing, Acoustic forces, Daughter droplets, Fold enrichments, Particle concentrations, Polystyrene beads, Two phase systems, Drops
IdentifiersURN: urn:nbn:se:kth:diva-194653ScopusID: 2-s2.0-84983266550ISBN: 9780979806483OAI: oai:DiVA.org:kth-194653DiVA: diva2:1050587
19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015, 25 October 2015 through 29 October 2015
Funding Details: Swedish Research Council
QC 201611292016-11-292016-10-312016-11-29Bibliographically approved