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Separate and combined effects of hypoxia and horizontal bed rest on retinal blood vessel diameters
KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology.
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2016 (English)In: Investigative Ophthalmology and Visual Science, ISSN 0146-0404, E-ISSN 1552-5783, Vol. 57, no 11, 4927-4932 p.Article in journal (Refereed) Published
Abstract [en]

PURPOSE. To assess the separate and combined effects of exposure to prolonged and sustained recumbency (bed rest) and hypoxia on retinal microcirculation. METHODS. Eleven healthy male subjects (mean 6 SD age = 27 ± 6 years; body mass index [BMI] = 23.7 ± 3.0 kg m-2) participated in a repeated-measures crossover design study comprising three 21-day interventions: normoxic bed rest (NBR; partial pressure of inspired O2, PiO2 = 133.1 ± 0.3 mm Hg); hypoxic ambulation (HAMB; PiO2 = 90.0 6 0.4 mm Hg), and hypoxic bed rest (HBR; PiO2 = 90.0 ± 0.4 mm Hg). Central retinal arteriolar (CRAE) and venular (CRVE) equivalents were measured at baseline and at regular intervals during each 21- day intervention. RESULTS. Normoxic bed rest caused a progressive reduction in CRAE, with the change in CRAE relative to baseline being highest on day 15 (ΔDCRAE = -7.5 µm; 95% confidence interval [CI]: -10.8 to -4.2; P < 0.0001). Hypoxic ambulation resulted in a persistent 21-day increase in CRAE, reaching a maximum on day 4 (DCRAE = 9.4 µm; 95% CI: 6.0-12.7; P < 0.0001). During HBR, the increase in CRAE was highest on day 3 (ΔDCRAE = 4.5 µm; 95% CI: 1.2-7.8; P = 0.007), but CRAE returned to baseline levels thereafter. Central retinal venular equivalent decreased during NBR and increased during HAMB and HBR. The reduction in CRVE during NBR was highest on day 1 (ΔDCRVE = -7.9 µm; 95 CI: -13.3 to -2.5), and the maximum ΔDCRVE during HAMB (24.6 µm; 95% CI: 18.9-30.3) and HBR (15.2 µm; 95% CI: 9.8-20.5) was observed on days 10 and 3, respectively. CONCLUSIONS. The diameters of retinal blood vessels exhibited a dynamic response to hypoxia and bed rest, such that retinal vasodilation was smaller during combined bed rest and hypoxia than during hypoxic exposure.

Place, publisher, year, edition, pages
Association for Research in Vision and Ophthalmology Inc. , 2016. Vol. 57, no 11, 4927-4932 p.
Keyword [en]
Bed rest, Hypoxia, Microvasculature, Physical inactivity, Retina
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:kth:diva-194915DOI: 10.1167/iovs.16-19968ISI: 000390156400049Scopus ID: 2-s2.0-84988942309OAI: oai:DiVA.org:kth-194915DiVA: diva2:1051346
Note

QC 20161201

Available from: 2016-12-01 Created: 2016-11-01 Last updated: 2017-01-16Bibliographically approved

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