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Integration of a Droplet-Based Microfluidic System and Silicon Nanoribbon FET Sensor
KTH, School of Information and Communication Technology (ICT). (Linnros)ORCID iD: 0000-0002-1002-6699
KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology.ORCID iD: 0000-0001-7510-0864
KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology.
ACREO Swedish ICT.
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2016 (English)In: Micromachines, ISSN 2072-666X, E-ISSN 2072-666XArticle in journal (Refereed) Published
Abstract [en]

We present a novel microfluidic system that integrates droplet microfluidics with a silicon nanoribbon field-effect transistor (SiNR FET), and utilize this integrated system to sense differences in pH. The device allows for selective droplet transfer to a continuous water phase, actuated by dielectrophoresis, and subsequent detection of the pH level in the retrieved droplets by SiNR FETs on an electrical sensor chip. The integrated microfluidic system demonstrates a label-free detection method for droplet microfluidics, presenting an alternative to optical fluorescence detection. In this work, we were able to differentiate between droplet trains of one pH-unit difference. The pH-based detection method in our integrated system has the potential to be utilized in the detection of biochemical reactions that induce a pH-shift in the droplets.

Place, publisher, year, edition, pages
MDPI AG , 2016.
Keyword [en]
NanoFET; silicon nanoribbon; droplet microfluidics; pH measurement
National Category
Nano Technology
Research subject
Biotechnology
Identifiers
URN: urn:nbn:se:kth:diva-198102DOI: 10.3390/mi7080134ISI: 000382467700006ScopusID: 2-s2.0-84984791952OAI: oai:DiVA.org:kth-198102DiVA: diva2:1055529
Funder
Knut and Alice Wallenberg Foundation
Note

QC 20161213

Available from: 2016-12-12 Created: 2016-12-12 Last updated: 2016-12-13Bibliographically approved

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Afrasiabi, RoodabehSöderberg, LovisaJönsson, HåkanAndersson-Svahn, Helene
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