Integration of a Droplet-Based Microfluidic System and Silicon Nanoribbon FET Sensor
2016 (English)In: Micromachines, ISSN 2072-666X, E-ISSN 2072-666XArticle in journal (Refereed) Published
We present a novel microfluidic system that integrates droplet microfluidics with a silicon nanoribbon field-effect transistor (SiNR FET), and utilize this integrated system to sense differences in pH. The device allows for selective droplet transfer to a continuous water phase, actuated by dielectrophoresis, and subsequent detection of the pH level in the retrieved droplets by SiNR FETs on an electrical sensor chip. The integrated microfluidic system demonstrates a label-free detection method for droplet microfluidics, presenting an alternative to optical fluorescence detection. In this work, we were able to differentiate between droplet trains of one pH-unit difference. The pH-based detection method in our integrated system has the potential to be utilized in the detection of biochemical reactions that induce a pH-shift in the droplets.
Place, publisher, year, edition, pages
MDPI AG , 2016.
NanoFET; silicon nanoribbon; droplet microfluidics; pH measurement
Research subject Biotechnology
IdentifiersURN: urn:nbn:se:kth:diva-198102DOI: 10.3390/mi7080134ISI: 000382467700006ScopusID: 2-s2.0-84984791952OAI: oai:DiVA.org:kth-198102DiVA: diva2:1055529
FunderKnut and Alice Wallenberg Foundation
QC 201612132016-12-122016-12-122016-12-13Bibliographically approved