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Binding modes of a core-extended metalloporphyrin to human telomeric DNA G-quadruplexes
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2015 (English)In: Organic and biomolecular chemistry, ISSN 1477-0520, E-ISSN 1477-0539, Vol. 13, no 8, p. 2453-2463Article in journal (Refereed) Published
Abstract [en]

The molecular recognition of human telomeric G-quadruplexes by a novel cationic π-extended NiII-porphyrin (NiII-TImidP4) is studied in aqueous solutions via (chir)optical spectroscopy, Fluorescence Resonance Energy Transfer (FRET) melting assay, and computational molecular modeling. The results are systematically compared with the recognition by a conventional meso-substituted NiII-porphyrin (NiII-TMPyP4), which allows us to pinpoint the differences in binding modes depending on the G-quadruplex topology. Importantly, FRET melting assays show the higher selectivity of NiII-TImidP4 towards human telomeric G4 than that of NiII-TMPyP4.

Place, publisher, year, edition, pages
Royal Society of Chemistry, 2015. Vol. 13, no 8, p. 2453-2463
Keywords [en]
Assays, DNA sequences, Energy transfer, Fluorescence, Melting, Nickel, Porphyrins, Binding modes, Computational molecular modeling, Fluorescence resonance energy transfer, G-quadruplexes, Human telomeric DNA, Metalloporphyrins, Optical spectroscopy, Binding energy, guanine quadruplex, metalloporphyrin, binding site, chemical structure, chemistry, human, telomere, Binding Sites, Humans, Models, Molecular, Molecular Structure
National Category
Theoretical Chemistry
Identifiers
URN: urn:nbn:se:kth:diva-198716DOI: 10.1039/c4ob02097aISI: 000349669300033PubMedID: 25563845Scopus ID: 2-s2.0-84922791136OAI: oai:DiVA.org:kth-198716DiVA, id: diva2:1059123
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QC 20161222

Available from: 2016-12-22 Created: 2016-12-21 Last updated: 2017-11-29Bibliographically approved

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