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A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates
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2015 (English)In: Chemistry - A European Journal, ISSN 0947-6539, E-ISSN 1521-3765, Vol. 21, no 43, 15133-15137 p.Article in journal (Refereed) Published
Abstract [en]

By replacing the central thiophene unit of an anionic pentameric oligothiophene with other heterocyclic moities, a palette of pentameric thiophene-based ligands with distinct fluorescent properties were synthesized. All ligands displayed superior selectivity towards recombinant amyloid fibrils as well as disease-associated protein aggregates in tissue sections.

Place, publisher, year, edition, pages
Wiley-VCH Verlagsgesellschaft, 2015. Vol. 21, no 43, 15133-15137 p.
Keyword [en]
Alzheimer's disease, fluorescent probes, luminescence, microscopy, oligothiophenes, Aggregates, Fluorescence, Microscopic examination, Neurodegenerative diseases, Proteins, Recombinant proteins, Synthesis (chemical), Thiophene, Amyloid fibril, Disease-associated proteins, Fluorescent property, Identification of proteins, Tissue sections, Ligands
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Theoretical Chemistry
Identifiers
URN: urn:nbn:se:kth:diva-198709DOI: 10.1002/chem.201502999ISI: 000363332200011PubMedID: 26388448ScopusID: 2-s2.0-84944704036OAI: oai:DiVA.org:kth-198709DiVA: diva2:1059133
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QC 20161222

Available from: 2016-12-22 Created: 2016-12-21 Last updated: 2016-12-22Bibliographically approved

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Norman, Patrick
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