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Effects of acute and long-term hypoxia on local cold tolerance
KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology.ORCID iD: 0000-0002-7440-2171
2016 (English)Conference paper, Oral presentation with published abstract (Refereed)
Abstract [en]

Exposure to high altitude is commonly considered a predisposing factor for local cold injury. A number of field studies have indeed confirmed that local cold tolerance is impaired in low-oxygen environments, presumably due to hypoxia-induced cutaneous vasoconstriction. However, during acute and long-term high-altitude exposure, the hypoxic stressor typically co-exists with other environmental and behavioral components, viz. hypothermia, malnutrition and physical fatigue, which independently or interactively may affect peripheral blood-flow responses. Laboratory-based, control studies have demonstrated that acute exposure to hypoxia, isolated from other confounding factors, does not potentiate vasoconstriction during local cold stress, but delays spontaneous rewarming following such cold stress. Conversely, it appears that long-term exposure to hypoxia elicits adaptive processes, in particular when the high-altitude acclimatization regimen is combined with physical exercise, that reverse the hypoxia-induced vasoconstriction after local limb cooling. Such adaptive responses do, however, not seem to be transferable to sea-level conditions, i.e. they do not reduce vasoconstriction during normoxic conditions, nor to be homogeneous across the limbs.

Place, publisher, year, edition, pages
2016.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:kth:diva-199245OAI: oai:DiVA.org:kth-199245DiVA, id: diva2:1061500
Conference
6th International Conference on the Physiology and Pharmacology of Temperature Regulation. December 5-9, Ljubljana, Slovenia.
Note

QC 20170112

Available from: 2017-01-02 Created: 2017-01-02 Last updated: 2017-01-12Bibliographically approved

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http://www.pptr2016.org/

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Keramidas, Michail E.

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