Derivation of a reversible Hill equation with modifiers affecting catalytic properties
2004 (English)In: WSEAS Transactions on Biology and Medicine, Vol. 1, 91-98 p.Article in journal (Refereed) Published
An existing generic enzyme rate equation, the reversible Hill equation, was generalized to account for modifiers affecting the catalytical properties of the enzyme as well as for the case of several substrates and products. The resulting generalized reversible Hill (GRH) equation has relatively few but operationally well-defined parameters. Its usefulness is demonstrated by fitting it to experimental data on mammalian muscle phosphofructokinase. The fit is superior to that of previous models to the same data. The rate equation derived is suitable for replacing more complicated rate equations when exact mechanisms are unknown and data is scarce or contradictory.
Place, publisher, year, edition, pages
2004. Vol. 1, 91-98 p.
Metabolic Modeling, Enzyme Kinetics, Reversible Hill Equation, Operationally Welldefined parameters, Phosphofructokinase
Computer and Information Science
IdentifiersURN: urn:nbn:se:kth:diva-6057OAI: oai:DiVA.org:kth-6057DiVA: diva2:10651
QC 201111102005-09-072005-09-072011-12-29Bibliographically approved