Glucose-stimulated insulin secretion - insights from modelling
2004 (English)In: Recent Research Developments in Biophysics, Vol. 3, 325-350 p.Article in journal (Refereed) Published
Insulin is secreted by the pancreatic β-cells in response to a raised blood glucose concentration. Glucose-stimulated insulin secretion (GSIS) is pulsatile and correlated with bursting electrical activity. We review the current understanding of pancreatic p-cell GSIS from a mathematical modelling perspective. We discuss the glycolysis and the mitochondrial metabolism and metabolic modelling thereof. In particular, we describe the theoretical basis for the hypothesis of an oscillatory glycolysis, which may be the cause of the pulsatile secretion. We also discuss the electrophysiology of the P-cell and present insights gained from mathematical modelling in this context. There are important causal connections between β-cell metabolism and electrophysiology. This brings about an unusual challenge for theoretical and computational biologists.
Place, publisher, year, edition, pages
2004. Vol. 3, 325-350 p.
Pancreatic hormone, Mathematical model, Electrophysiology, Review, Stimulation, Secretion, Insulin, Glucose
Computer and Information Science
IdentifiersURN: urn:nbn:se:kth:diva-6058OAI: oai:DiVA.org:kth-6058DiVA: diva2:10652
QC 201111102005-09-072005-09-072011-12-29Bibliographically approved