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Flexible and Stretchable Microneedle Patches with Integrated Rigid Stainless Steel Microneedles for Transdermal Biointerfacing
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.ORCID iD: 0000-0003-4322-6192
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
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2016 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 11, no 12, article id e0166330Article in journal (Refereed) Published
Abstract [en]

This paper demonstrates flexible and stretchable microneedle patches that combine soft and flexible base substrates with hard and sharp stainless steel microneedles. An elastomeric polymer base enables conformal contact between the microneedle patch and the complex topography and texture of the underlying skin, while robust and sharp stainless steel microneedles reliably pierce the outer layers of the skin. The flexible microneedle patches have been realized by magnetically assembling short stainless steel microneedles into a flexible polymer supporting base. In our experimental investigation, the microneedle patches were applied to human skin and an excellent adaptation of the patch to the wrinkles and deformations of the skin was verified, while at the same time the microneedles reliably penetrate the surface of the skin. The unobtrusive flexible and stretchable microneedle patches have great potential for transdermal biointerfacing in a variety of emerging applications such as transdermal drug delivery, bioelectric treatments and wearable bio-electronics for health and fitness monitoring.

Place, publisher, year, edition, pages
Public Library of Science , 2016. Vol. 11, no 12, article id e0166330
National Category
Polymer Technologies Medical Biotechnology
Identifiers
URN: urn:nbn:se:kth:diva-199482DOI: 10.1371/journal.pone.0166330ISI: 000389587100025Scopus ID: 2-s2.0-85006051781OAI: oai:DiVA.org:kth-199482DiVA, id: diva2:1067349
Note

QC 20170120

Available from: 2017-01-20 Created: 2017-01-09 Last updated: 2019-03-06Bibliographically approved
In thesis
1. Flexible and Stretchable Biointerfacing for Healthcare Diagnostics
Open this publication in new window or tab >>Flexible and Stretchable Biointerfacing for Healthcare Diagnostics
2019 (English)Licentiate thesis, comprehensive summary (Other academic)
Abstract [en]

Flexible and stretchable wearable biomedical devices provide a platform for continues long-term monitoring of biological signals during neutral body movements thus enabling early intervention and diagnostics of various diseases. This thesis evaluates novel flexible and stretchable bio interfacing medical devices based on microneedle patches and split ring resonator for healthcare diagnostics. Flexible and stretchable microneedle patches were realized by integrating a soft polymer substrate with sharp stainless steel microneedles. This was realized using a magnetic assembly technique. Investigations have shown that the flexible microneedle patch can provide conformal and reliable contact with wrinkles and deformations of the skin. In addition, transdermal monitoring of potassium ions using the proposed flexible microneedle patch have been demonstrated by coating the microneedles with a potassium sensing membrane. Ex-vivo test on the microneedle potassium sensor performed on chicken and porcine skin was able to detect change in potassium concentration in the skin. Furthermore, a novel flexible bio-interface spilt ring resonator (SRR) for the monitoring of intera cranial pressure (ICP) is demonstrated. The sensor was fabricated by depositing a 500 nm gold film on a thermoset thiolene epoxy polymer substrate. The flexible sensor was able to clearly detect the pressure variation that might be an indication of increased ICP in the skull. The proposed methodology of heterogeneous integration of hard materials on a soft and flexible substrate demonstrates a first proof of concept of flexible wearable bio-interfacing devices with vastly different material properties with the potential for continuous and real-time health monitoring.

Place, publisher, year, edition, pages
KTH Royal Institute of Technology, 2019. p. 36
Series
TRITA-EECS-AVL ; 2019:22
Keywords
Wearable biointerfacing sensor, flexible and stretchable microneedles patch, wearable microneedles device, health and fitness monitoring, minimally invasive ICP monitoring, bioelectronics
National Category
Engineering and Technology
Research subject
Electrical Engineering
Identifiers
urn:nbn:se:kth:diva-245075 (URN)978-91-7873-128-2 (ISBN)
Presentation
2019-03-27, Q34, Kungliga Tekniska högskolan, Malvinas väg 6, Stockholm, 10:00 (English)
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Supervisors
Note

QC 20190306

Available from: 2019-03-06 Created: 2019-03-05 Last updated: 2019-03-06Bibliographically approved

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Shafagh, Reza ZandiFischer, Andreas C.van der Wijngaart, WouterStemme, GöranNiklaus, Frank

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