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Acetylene-sourced CVD-synthesised catalytically active graphene for electrochemical biosensing
KTH, School of Biotechnology (BIO), Theoretical Chemistry and Biology. (Virtual Laboratory for Molecular Probes)ORCID iD: 0000-0003-0185-5724
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2017 (English)In: Biosensors and Bioelectronics, ISSN 0956-5663, Vol. 89, p. 496-504Article in journal (Refereed) Published
Abstract [en]

In this study, we have demonstrated the use of chemical vapour deposition (CVD) grown-graphene to develop a highly-ordered graphene-enzyme electrode for electrochemical biosensing. The graphene sheets were deposited on 1.00 mm thick copper sheet at 850 degrees C using acetylene (C2H2) as carbon source in an argon (Ar) and nitrogen (N-2) atmosphere. An anionic surfactant was used to increase wettability and hydrophilicity of graphene; thereby facilitating the assembly of biomolecules on the electrode surface. Meanwhile, the theoretical calculations confirmed the successful modification of hydrophobic nature of graphene through the anionic surface assembly, which allowed high-ordered immobilisation of glucose oxidase (GOx) on the graphene. The electrochemical sensing activities of the graphene-electrode was explored as a model for bioelectrocatalysis. The bioelectrode exhibited a linear response to glucose concentration ranging from 0.2 to 9.8 mM, with sensitivity of 0.087 A/M/cm(2) and a detection limit of 0.12 mu M (S/N=3). This work sets the stage for the use of acetylene-sourced CVD-grown graphene as a fundamental building block in the fabrication of electrochemical biosensors and other bioelectronic devices.

Place, publisher, year, edition, pages
Elsevier, 2017. Vol. 89, p. 496-504
Keywords [en]
CVD-grown graphene, bioelectronics, theoretical calculation, surfactant modification, 2d-materials
National Category
Biophysics
Identifiers
URN: urn:nbn:se:kth:diva-200394DOI: 10.1016/j.bios.2016.03.063ISI: 000391077000048PubMedID: 27157880Scopus ID: 2-s2.0-85013834040OAI: oai:DiVA.org:kth-200394DiVA, id: diva2:1069128
Funder
Swedish Research Council, VR-2011-6058357
Note

QC 20170127

Available from: 2017-01-27 Created: 2017-01-27 Last updated: 2017-01-27Bibliographically approved

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CiteExportLink to record
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