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Ultra-miniaturization of a planar amperometric sensor targeting continuous intradermal glucose monitoring
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.ORCID iD: 0000-0002-3549-0228
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.ORCID iD: 0000-0001-9552-4234
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
2017 (English)In: Biosensors & bioelectronics, ISSN 0956-5663, E-ISSN 1873-4235, Vol. 90, p. 577-583Article in journal (Refereed) Published
Abstract [en]

An ultra-miniaturized electrochemical biosensor for continuous glucose monitoring (CGM) is presented. The aim of this work is to demonstrate the possibility of an overall reduction in sensor size to allow minimally invasive glucose monitoring in the interstitial fluid in the dermal region, in contrast to larger state-of-the-art systems, which are necessarily placed in the subcutaneous layer. Moreover, the reduction in size might be a key factor to improve the stability and reliability of transdermal sensors, due to the reduction of the detrimental foreign body reaction and of consequent potential failures. These advantages are combined with lower invasiveness and discomfort for patients. The realized device consists of a microfabricated three-electrode enzymatic sensor with a total surface area of the sensing portion of less than 0.04 mm2, making it the smallest fully integrated planar amperometric glucose sensor area reported to date. The working electrode and counter electrode consist of platinum and are functionalized by drop casting of three polymeric membranes. The on-chip iridium oxide (IrOx) pseudo-reference electrode provides the required stability for measurements under physiological conditions. The device is able to dynamically and linearly measure glucose concentrations in-vitro over the relevant physiological range, while showing sufficient selectivity to known interfering species present in the interstitial fluid, with resolution and sensitivity (1.51 nA/mM) comparable to that of state-of-art commercial CGM systems. This work can therefore enable less invasive and improved CGM in patients affected by diabetes.

Place, publisher, year, edition, pages
Elsevier, 2017. Vol. 90, p. 577-583
Keywords [en]
Amperometry, Continuous glucose monitoring, Diabetes, Glucose biosensor, Iridium oxide reference electrode, MEMS
National Category
Other Engineering and Technologies
Identifiers
URN: urn:nbn:se:kth:diva-200851DOI: 10.1016/j.bios.2016.10.007ISI: 000392768000073Scopus ID: 2-s2.0-85006170204OAI: oai:DiVA.org:kth-200851DiVA, id: diva2:1071595
Note

QC 20170206

Available from: 2017-02-06 Created: 2017-02-03 Last updated: 2017-11-29Bibliographically approved

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