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Rhamnogalacturonan-I based microcapsules for targeted drug release
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2016 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 11, no 12, article id e0168050Article in journal (Refereed) Published
Abstract [en]

Drug targeting to the colon via the oral administration route for local treatment of e.g. inflammatory bowel disease and colonic cancer has several advantages such as needle-free administration and low infection risk. A new source for delivery is plant-polysaccharide based delivery platforms such as Rhamnogalacturonan-I (RG-I). In the gastro-intestinal tract the RG-I is only degraded by the action of the colonic microflora. For assessment of potential drug delivery properties, RG-I based microcapsules (~1 μm in diameter) were prepared by an interfacial poly-addition reaction. The cross-linked capsules were loaded with a fluorescent dye (model drug). The capsules showed negligible and very little in vitro release when subjected to media simulating gastric and intestinal fluids, respectively. However, upon exposure to a cocktail of commercial RG-I cleaving enzymes, ~ 9 times higher release was observed, demonstrating that the capsules can be opened by enzymatic degradation. The combined results suggest a potential platform for targeted drug delivery in the terminal gastro-intestinal tract.

Place, publisher, year, edition, pages
Public Library of Science , 2016. Vol. 11, no 12, article id e0168050
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Pharmaceutical Sciences
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URN: urn:nbn:se:kth:diva-201491DOI: 10.1371/journal.pone.0168050Scopus ID: 2-s2.0-85006930226OAI: oai:DiVA.org:kth-201491DiVA, id: diva2:1073468
Note

QC 20170210

Available from: 2017-02-10 Created: 2017-02-10 Last updated: 2018-01-13Bibliographically approved

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