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Detection and Spatial Analysis of Hepatic Steatosis in Histopathology Images using Sparse Linear Models
KTH, School of Technology and Health (STH).ORCID iD: 0000-0003-2312-6119
2016 (English)In: 2016 SIXTH INTERNATIONAL CONFERENCE ON IMAGE PROCESSING THEORY, TOOLS AND APPLICATIONS (IPTA), IEEE, 2016Conference paper, (Refereed)
Abstract [en]

Hepatic steatosis is a defining feature of nonalcoholic fatty liver disease, emerging with the increasing incidence of obesity and metabolic syndrome. The research in image-based analysis of hepatic steatosis mostly focuses on the quantification of fat in biopsy images. This work furthers the image-based analysis of hepatic steatosis by exploring the spatial characteristics of fat globules in whole slide biopsy images after performing fat detection. An algorithm based on morphological filtering and sparse linear models is presented for fat detection. Then the spatial properties of detected fat globules in relation to the hepatic anatomical structures of central veins and portal tracts are explored. The test dataset consists of 38 high resolution images from 21 patients. The experimental results provide an insight into the size distributions of fat globules and their location with respect to the anatomical structures.

Place, publisher, year, edition, pages
IEEE, 2016.
Series
International Conference on Image Processing Theory Tools and Applications, ISSN 2154-512X
Keyword [en]
Hepatic steatosis, nonalcoholic fatty liver disease, liver fat detection, spatial analysis, digital pathology, biopsy image analysis, sparse linear models, shape classification, dictionary-based algorithm
National Category
Medical Engineering Clinical Medicine
Identifiers
URN: urn:nbn:se:kth:diva-203848DOI: 10.1109/IPTA.2016.7820969ISI: 000393589800021Scopus ID: 2-s2.0-85013187947ISBN: 978-1-4673-8910-5 (print)OAI: oai:DiVA.org:kth-203848DiVA: diva2:1083156
Conference
6th International Conference on Image Processing Theory, Tools and Applications (IPTA), DEC 12-15, 2016, Oulu, FINLAND
Note

QC 20170320

Available from: 2017-03-20 Created: 2017-03-20 Last updated: 2017-03-20Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
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  • modern-language-association-8th-edition
  • vancouver
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Language
  • de-DE
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  • fi-FI
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