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Biomimetic spinning of artificial spider silk from a chimeric minispidroin
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2017 (English)In: Nature Chemical Biology, ISSN 1552-4450, E-ISSN 1552-4469, Vol. 13, no 3, 262-+ p.Article in journal (Refereed) Published
Abstract [en]

Herein we present a chimeric recombinant spider silk protein (spidroin) whose aqueous solubility equals that of native spider silk dope and a spinning device that is based solely on aqueous buffers, shear forces and lowered pH. The process recapitulates the complex molecular mechanisms that dictate native spider silk spinning and is highly efficient; spidroin from one liter of bacterial shake-flask culture is enough to spin a kilometer of the hitherto toughest as-spun artificial spider silk fiber.

Place, publisher, year, edition, pages
Nature Publishing Group, 2017. Vol. 13, no 3, 262-+ p.
National Category
Biological Sciences
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URN: urn:nbn:se:kth:diva-204071DOI: 10.1038/NCHEMBIO.2269ISI: 000394431500006PubMedID: 28068309Scopus ID: 2-s2.0-85008658159OAI: oai:DiVA.org:kth-204071DiVA: diva2:1085507
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QC 20170329

Available from: 2017-03-29 Created: 2017-03-29 Last updated: 2017-03-29Bibliographically approved

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Purhonen, PasiHebert, HansPlaza, Gustavo R.
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School of Technology and Health (STH)Structural Biotechnology
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