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Carbohydrate-based particles reduce allergic inflammation in a mouse model for cat allergy
Karolinska Institutet, Sweden.ORCID iD: 0000-0003-4822-3759
Karolinska Institutet, Sweden.
Medical University Vienna, Austria.
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2008 (English)In: Allergy. European Journal of Allergy and Clinical Immunology, ISSN 0105-4538, E-ISSN 1398-9995, Vol. 63, no 5, 518-526 p.Article in journal (Refereed) Published
Abstract [en]

Background: Allergen-specific immunotherapy (ASIT) is the only treatment of allergic disease that gives long-lasting relief of symptoms. However, concerns for safety and efficiency have highlighted the need for improvement of the therapy. We have previously suggested carbohydrate-based particles (CBPs) as a novel adjuvant and allergen carrier for ASIT. Our aim of this study was to evaluate the therapeutic potential of CBPs in ASIT, employing a mouse model for cat allergy. Methods: BALB/c mice were subcutaneously immunized with the recombinant (r) cat allergen Fel d 1 followed by intranasal challenge with cat dander extract (CDE). The sensitized mice were therapeutically treated with rFel d 1 covalently coupled to CBPs (CBP-rFel d 1). Airway hyper-reactivity (AHR), infiltration of leucocytes in bronchoalveolar lavage (BAL) fluid, allergen-specific serum immunoglobulin levels and in vitro splenocyte responses were evaluated. Results: Mice treated with CBP-rFel d 1 showed reduced features of allergic inflammation. They responded with (i) significantly decreased AHR and infiltration of eosinophils in BAL fluid after CDE challenge, (ii) the serum level of rFel d 1-specific IgE was reduced and the level of IgG(2)a was more pronounced after CBP-rFel d 1 treatment, and (iii) there was also a tendency of decreased allergen-specific cellular response. Conclusions: Carbohydrate-based particles are effective tools as adjuvant and allergen carriers for use in ASIT and constitutes a promising strategy to improve allergy treatment.

Place, publisher, year, edition, pages
John Wiley & Sons, 2008. Vol. 63, no 5, 518-526 p.
National Category
Basic Medicine
Identifiers
URN: urn:nbn:se:kth:diva-205254DOI: 10.1111/j.1398-9995.2008.01644.xISI: 000254638700005ScopusID: 2-s2.0-41749086951OAI: oai:DiVA.org:kth-205254DiVA: diva2:1088053
Note

QC 20170419

Available from: 2017-04-11 Created: 2017-04-11 Last updated: 2017-04-19Bibliographically approved

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