Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Comprehensive RNA sequencing of healthy human endometrium at two time points of the menstrual cycle
KTH, Centres, Science for Life Laboratory, SciLifeLab. KTH, School of Biotechnology (BIO).
Karolinska Inst, Dept Clin Sci & Educ, Unit Obstet & Gynecol, Sjukhusbacken 10, S-11883 Stockholm, Sweden.
KTH, School of Biotechnology (BIO), Gene Technology. KTH, Centres, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0002-2219-0197
Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.
Show others and affiliations
2017 (English)In: Biology of Reproduction, ISSN 0006-3363, E-ISSN 1529-7268, Vol. 96, no 1, p. 24-33Article in journal (Refereed) Published
Abstract [en]

Endometrial receptivity is crucial for implantation and establishment of a normal pregnancy. The shift from proliferative to receptive endometrium is still far from being understood. In this paper, we comprehensively present the transcriptome of the human endometrium by comparing endometrial biopsies from proliferative phase with consecutive biopsies 7-9 days after ovulation. The results show a clear difference in expression between the two time points using both total and small RNA sequencing. A total of 3,297 messenger RNAs (mRNAs), 516 long noncoding RNAs (lncRNAs), and 102 small noncoding RNAs were identified as statistically differentially expressed between the two time points. We show a thorough description of the change in mRNA between the two time points and display lncRNAs, small nucleolar RNAs, and small nuclear RNAs not previously reported in the healthy human endometrium. In conclusion, this paper reports in detail the shift in RNA expression from the proliferative to receptive endometrium. Summary Sentence Messenger RNA, sncRNA, and lncRNA show a clear difference in expression between proliferative phase and 7-9 days after ovulation, thoroughly described together with lncRNA, snoRNA, and snRNA not previously reported in healthy human endometrium.

Place, publisher, year, edition, pages
SOC STUDY REPRODUCTION , 2017. Vol. 96, no 1, p. 24-33
Keywords [en]
endometrium, receptivity, RNA sequencing
National Category
Genetics
Identifiers
URN: urn:nbn:se:kth:diva-205153DOI: 10.1095/biolreprod.116.142547ISI: 000397307400004Scopus ID: 2-s2.0-85022337463OAI: oai:DiVA.org:kth-205153DiVA, id: diva2:1088436
Funder
Science for Life Laboratory - a national resource center for high-throughput molecular bioscience
Note

QC 20170412

Available from: 2017-04-12 Created: 2017-04-12 Last updated: 2018-06-18Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textScopushttps://www.ncbi.nlm.nih.gov/pubmed/28395321https://academic.oup.com/biolreprod/article-lookup/doi/10.1095/biolreprod.116.142547

Authority records BETA

Jemt, AndersLundeberg, Joakim

Search in DiVA

By author/editor
Sigurgeirsson, BenjaminJemt, AndersLundeberg, Joakim
By organisation
Science for Life Laboratory, SciLifeLabSchool of Biotechnology (BIO)Gene Technology
In the same journal
Biology of Reproduction
Genetics

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 42 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf