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Comprehensive RNA sequencing of healthy human endometrium at two time points of the menstrual cycle
KTH, School of Biotechnology (BIO), Gene Technology.ORCID iD: 0000-0002-2219-0197
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2017 (English)In: Biology of Reproduction, ISSN 0006-3363, E-ISSN 1529-7268, Vol. 96, no 1, 24-33 p.Article in journal (Refereed) Published
Abstract [en]

Endometrial receptivity is crucial for implantation and establishment of a normal pregnancy. The shift from proliferative to receptive endometrium is still far from being understood. In this paper, we comprehensively present the transcriptome of the human endometrium by comparing endometrial biopsies from proliferative phase with consecutive biopsies 7-9 days after ovulation. The results show a clear difference in expression between the two time points using both total and small RNA sequencing. A total of 3,297 messenger RNAs (mRNAs), 516 long noncoding RNAs (lncRNAs), and 102 small noncoding RNAs were identified as statistically differentially expressed between the two time points. We show a thorough description of the change in mRNA between the two time points and display lncRNAs, small nucleolar RNAs, and small nuclear RNAs not previously reported in the healthy human endometrium. In conclusion, this paper reports in detail the shift in RNA expression from the proliferative to receptive endometrium. Summary Sentence Messenger RNA, sncRNA, and lncRNA show a clear difference in expression between proliferative phase and 7-9 days after ovulation, thoroughly described together with lncRNA, snoRNA, and snRNA not previously reported in healthy human endometrium.

Place, publisher, year, edition, pages
SOC STUDY REPRODUCTION , 2017. Vol. 96, no 1, 24-33 p.
Keyword [en]
endometrium, receptivity, RNA sequencing
National Category
Genetics
Identifiers
URN: urn:nbn:se:kth:diva-205153DOI: 10.1095/biolreprod.116.142547ISI: 000397307400004OAI: oai:DiVA.org:kth-205153DiVA: diva2:1088436
Note

QC 20170412

Available from: 2017-04-12 Created: 2017-04-12 Last updated: 2017-05-22Bibliographically approved

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Publisher's full texthttps://www.ncbi.nlm.nih.gov/pubmed/28395321https://academic.oup.com/biolreprod/article-lookup/doi/10.1095/biolreprod.116.142547

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Sigurgeirsson, BenjaminJemt, AndersLundeberg, Joakim
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CiteExportLink to record
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Citation style
  • apa
  • harvard1
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