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Polyhydroxyalkanoate-based drug delivery systems
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology.ORCID iD: 0000-0002-7790-8987
2017 (English)In: Polymer international, ISSN 0959-8103, E-ISSN 1097-0126, Vol. 66, no 5, 617-622 p.Article, review/survey (Refereed) Published
Abstract [en]

Microbial polyhydroxyalkanoates (PHAs) have been a subject of significant research interest in the past few decades. The recent development of novel functionalized PHAs has opened up new possibilities to combine the good biocompatibility of PHA-based drug delivery systems to, for example, improve drug loading and release properties, targeting or imaging functionalities. This mini-review presents some recent scientific developments in the preparation of functionalized PHAs, PHA-drug and PHA-protein conjugates, multifunctional PHA nanoparticles and micelles as well as biosynthetic PHA particles for drug delivery. These developments in combination with the generally excellent biocompatibility of PHA materials are expected to further expand the interest in PHA materials for drug delivery and other therapeutic applications.

Place, publisher, year, edition, pages
WILEY , 2017. Vol. 66, no 5, 617-622 p.
Keyword [en]
polyhydroxyalkanoate, poly(3-hydroxybutyrate), drug delivery, nanoparticle, drug conjugate
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:kth:diva-206679DOI: 10.1002/pi.5282ISI: 000398731200001ScopusID: 2-s2.0-85006314759OAI: oai:DiVA.org:kth-206679DiVA: diva2:1094477
Note

QC 20170510

Available from: 2017-05-10 Created: 2017-05-10 Last updated: 2017-05-10Bibliographically approved

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