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Molecular processes in an electrochemical clozapine sensor
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
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2017 (English)In: Biointerphases, ISSN 1934-8630, E-ISSN 1559-4106, Vol. 12, no 2, article id 02B401Article in journal (Refereed) Published
Abstract [en]

Selectivity presents a crucial challenge in direct electrochemical sensing. One example is schizophrenia treatment monitoring of the redox-active antipsychotic clozapine. To accurately assess efficacy, differentiation from its metabolite norclozapine-similar in structure and redox potentialis critical. Here, the authors leverage biomaterials integration to study, and effect changes in, diffusion and electron transfer kinetics of these compounds. Specifically, the authors employ a catechol-modified chitosan film, which the authors have previously presented as the first electrochemical detection mechanism capable of quantifying clozapine directly in clinical serum. A key finding in our present work is differing dynamics between clozapine and norclozapine once the authors interface the electrodes with chitosan-based biomaterial films. These additional dimensions of redox information can thus enable selective sensing of largely analogous small molecules.

Place, publisher, year, edition, pages
American Institute of Physics (AIP), 2017. Vol. 12, no 2, article id 02B401
National Category
Textile, Rubber and Polymeric Materials
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URN: urn:nbn:se:kth:diva-207868DOI: 10.1116/1.4982709ISI: 000400683300002PubMedID: 28460529Scopus ID: 2-s2.0-85019004994OAI: oai:DiVA.org:kth-207868DiVA, id: diva2:1102709
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QC 20170530

Available from: 2017-05-30 Created: 2017-05-30 Last updated: 2017-05-30Bibliographically approved

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Winkler, Thomas

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