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Medial reward and lateral non-reward orbitofrontal cortex circuits change in opposite directions in depression
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2016 (English)In: Brain, ISSN 0006-8950, E-ISSN 1460-2156, Vol. 139, no 12, p. 3296-3309Article in journal (Refereed) Published
Abstract [en]

The first brain-wide voxel-level resting state functional connectivity neuroimaging analysis of depression is reported, with 421 patients with major depressive disorder and 488 control subjects. Resting state functional connectivity between different voxels reflects correlations of activity between those voxels and is a fundamental tool in helping to understand the brain regions with altered connectivity and function in depression. One major circuit with altered functional connectivity involved the medial orbitofrontal cortex Brodmann area 13, which is implicated in reward, and which had reduced functional connectivity in depression with memory systems in the parahippocampal gyrus and medial temporal lobe, especially involving the perirhinal cortex Brodmann area 36 and entorhinal cortex Brodmann area 28. The Hamilton Depression Rating Scale scores were correlated with weakened functional connectivity of the medial orbitofrontal cortex Brodmann area 13. Thus in depression there is decreased reward-related and memory system functional connectivity, and this is related to the depressed symptoms. The lateral orbitofrontal cortex Brodmann area 47/12, involved in non-reward and punishing events, did not have this reduced functional connectivity with memory systems. Second, the lateral orbitofrontal cortex Brodmann area 47/12 had increased functional connectivity with the precuneus, the angular gyrus, and the temporal visual cortex Brodmann area 21. This enhanced functional connectivity of the non-reward/punishment system (Brodmann area 47/12) with the precuneus (involved in the sense of self and agency), and the angular gyrus (involved in language) is thus related to the explicit affectively negative sense of the self, and of self-esteem, in depression. A comparison of the functional connectivity in 185 depressed patients not receiving medication and 182 patients receiving medication showed that the functional connectivity of the lateral orbitofrontal cortex Brodmann area 47/12 with these three brain areas was lower in the medicated than the unmedicated patients. This is consistent with the hypothesis that the increased functional connectivity of the lateral orbitofrontal cortex Brodmann area 47/12 is related to depression. Relating the changes in cortical connectivity to our understanding of the functions of different parts of the orbitofrontal cortex in emotion helps to provide new insight into the brain changes related to depression. © The Author (2016). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved.

Place, publisher, year, edition, pages
Oxford University Press , 2016. Vol. 139, no 12, p. 3296-3309
Keyword [en]
Depression, Functional connectivity, Medial temporal lobe, Orbitofrontal cortex, Precuneus
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:kth:diva-207567DOI: 10.1093/brain/aww255ISI: 000392709800027Scopus ID: 2-s2.0-85014830813OAI: oai:DiVA.org:kth-207567DiVA, id: diva2:1102714
Note

Export Date: 22 May 2017; Article; CODEN: BRAIA; Correspondence Address: Lin, C.-P.; Institute of Neuroscience, National Yang-Ming UniversityTaiwan; email: cplin@ym.edu.tw; Funding details: 11101429, NSFC, National Natural Science Foundation of China; Funding details: 11322111, NSFC, National Natural Science Foundation of China; Funding details: 11471081, NSFC, National Natural Science Foundation of China; Funding details: 2015M572423, China Postdoctoral Science Foundation; Funding details: 31271087, NSFC, National Natural Science Foundation of China; Funding details: 31271189, NSFC, National Natural Science Foundation of China; Funding details: 31470981, NSFC, National Natural Science Foundation of China; Funding details: 31500885, NSFC, National Natural Science Foundation of China; Funding details: 31571137, NSFC, National Natural Science Foundation of China; Funding details: 61104143, NSFC, National Natural Science Foundation of China; Funding details: 61273014, NSFC, National Natural Science Foundation of China; Funding details: 61573107, NSFC, National Natural Science Foundation of China; Funding details: 71661167002, NSFC, National Natural Science Foundation of China; Funding details: 81571331, NSFC, National Natural Science Foundation of China; Funding details: 91230201, CAS, Chinese Academy of Sciences; Funding details: 91230201, NSFC, National Natural Science Foundation of China; Funding details: AS-104-TP-B10, Academia Sinica; Funding details: cstc2015jcyjA10106, Natural Science Foundation of Chongqing; Funding details: DOH102-TD-PB-111-NSC006, MOHW, Ministry of Health and Welfare; Funding details: MOST 104-2218-E-010-007-MY3, MOST, Ministry of Science and Technology of the People's Republic of China; Funding details: MOST 104-2221-E-010-013, MOST, Ministry of Science and Technology of the People's Republic of China; Funding details: MOST 104-2633-B-400-001, MOST, Ministry of Science and Technology of the People's Republic of China; Funding details: NHRI-EX-10310EI, NHRI, National Health Research Institutes; Funding text: J.F. is a Royal Society Wolfson Research Merit Award holder. J. F. is also partially supported by the National High Technology Research and Development Program of China (No. 2015AA020507) and the key project of Shanghai Science and Technology Innovation Plan (No. 15JC1400101). The research was partially supported by the National Centre for Mathematics and Interdisciplinary Sciences (NCMIS) of the Chinese Academy of Sciences, Key Program of National Natural Science Foundation of China (No. 91230201), and the Shanghai Soft Science Research Program (No. 15692106604). W.C. is partly supported by grants from the National Natural Sciences Foundation of China (No.11471081, 11101429 and 71661167002). J.Z is supported by National Science Foundation of China (NSFC 61104143 and 61573107), and special Funds for Major State Basic Research Projects of China (2015CB856003). C.P.L was supported in part by funding from Ministry of Science and Technology (MOST 104-2633-B-400-001, MOST 104-2218-E-010-007-MY3, MOST 104-2221-E-010-013), Ministry of Health and Welfare (DOH102-TD-PB-111-NSC006), National Health Research Institutes (NHRI-EX-10310EI) and Academia Sinica (AS-104-TP-B10) of Taiwan. J.Q was supported by the National Natural Science Foundation of China (31271087; 31470981; 31571137; 31500885), National Outstanding young people plan, the Program for the Top Young Talents by Chongqing, the Fundamental Research Funds for the Central Universities (SWU1509383), Natural Science Foundation of Chongqing (cstc2015jcyjA10106), General Financial Grant from the China Postdoctoral Science Foundation (2015M572423). P.X. is supported by National Science Foundation of China (NSFC 31271189). W.L. was supported by the . Y.Q.T. was supported by grants from the National Natural Science Foundation of China (81571311; 81271499). F.W. was supported by a grant from the National Natural Science Foundation of China (81571331). QC 20170530

Available from: 2017-05-30 Created: 2017-05-30 Last updated: 2017-05-30Bibliographically approved

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