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Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage
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2017 (English)In: eLIFE, E-ISSN 2050-084X, Vol. 6, e25902Article in journal (Refereed) Published
Abstract [en]

Cartilaginous structures are at the core of embryo growth and shaping before the bone forms. Here we report a novel principle of vertebrate cartilage growth that is based on introducing transversally-oriented clones into pre-existing cartilage. This mechanism of growth uncouples the lateral expansion of curved cartilaginous sheets from the control of cartilage thickness, a process which might be the evolutionary mechanism underlying adaptations of facial shape. In rod-shaped cartilage structures (Meckel, ribs and skeletal elements in developing limbs), the transverse integration of clonal columns determines the well-defined diameter and resulting rod-like morphology. We were able to alter cartilage shape by experimentally manipulating clonal geometries. Using in silico modeling, we discovered that anisotropic proliferation might explain cartilage bending and groove formation at the macro-scale.

Place, publisher, year, edition, pages
Elife Sciences Publications LTD , 2017. Vol. 6, e25902
National Category
Bio Materials
Identifiers
URN: urn:nbn:se:kth:diva-207685DOI: 10.7554/eLife.25902ISI: 000400576600001Scopus ID: 2-s2.0-85019772217OAI: oai:DiVA.org:kth-207685DiVA: diva2:1104658
Funder
Swedish Society for Medical Research (SSMF)Swedish Research Council FormasThe Karolinska Institutet's Research FoundationÅke Wiberg FoundationScience for Life Laboratory - a national resource center for high-throughput molecular bioscience
Note

QC 20170601

Available from: 2017-06-01 Created: 2017-06-01 Last updated: 2017-11-10Bibliographically approved

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Brismar, Hjalmar
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CiteExportLink to record
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