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Distinguishing Individual DNA Bases in a Network by Non-Resonant Tip-Enhanced Raman Scattering
KTH, School of Biotechnology (BIO), Theoretical Chemistry and Biology.
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2017 (English)In: Angewandte Chemie International Edition, ISSN 1433-7851, E-ISSN 1521-3773, Vol. 56, no 20, 5561-5564 p.Article in journal (Refereed) Published
Abstract [en]

The importance of identifying DNA bases at the single-molecule level is well recognized for many biological applications. Although such identification can be achieved by electrical measurements using special setups, it is still not possible to identify single bases in real space by optical means owing to the diffraction limit. Herein, we demonstrate the outstanding ability of scanning tunneling microscope (STM)-controlled non-resonant tip-enhanced Raman scattering (TERS) to unambiguously distinguish two individual complementary DNA bases (adenine and thymine) with a spatial resolution down to 0.9 nm. The distinct Raman fingerprints identified for the two molecules allow to differentiate in real space individual DNA bases in coupled base pairs. The demonstrated ability of non-resonant Raman scattering with super-high spatial resolution will significantly extend the applicability of TERS, opening up new routes for singlemolecule DNA sequencing.

Place, publisher, year, edition, pages
WILEY-V C H VERLAG GMBH , 2017. Vol. 56, no 20, 5561-5564 p.
Keyword [en]
DNA bases, molecular recognition, non-resonant Raman spectroscopy, scanning tunneling microscopy, tip-enhanced Raman scattering
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:kth:diva-207657DOI: 10.1002/anie.201702263ISI: 000400458700027PubMedID: 28394094Scopus ID: 2-s2.0-85017444809OAI: oai:DiVA.org:kth-207657DiVA: diva2:1104951
Note

QC 20170602

Available from: 2017-06-02 Created: 2017-06-02 Last updated: 2017-06-02Bibliographically approved

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Luo, Yi

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