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The interplay of electrode- and bio-materials in a redox-cycling-based clozapine sensor
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
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2017 (English)In: Electrochemistry communications, ISSN 1388-2481, E-ISSN 1873-1902, Vol. 79, 33-36 p.Article in journal (Refereed) Published
Abstract [en]

We investigate gold, TiN, and platinum in combination with a chitosan catechol-based redox-cycling system (RCS) for electrochemical detection of the antipsychotic clozapine. We have previously demonstrated the RCS for detection of clozapine in serum, but challenges remain regarding low signal-to-noise ratios. This can be mitigated by selection of electrode materials with beneficial surface morphologies and/or compositions. We employ cyclic voltammetry to assess the redox current generated by clozapine, and differentiate solely surface area-based effects from clozapine-specific ones using a standard redox couple. We find that nano- and microstructured platinum greatly amplifies the clozapine signal compared to gold (up to 1490-fold for platinum black). However, the material performs poorly in the presence of chloride ions, and RCS modification provides no further amplification. The RCS combined with atomic-layer-deposited (ALD) TiN, on the other hand, increases the signal by 7.54 times, versus 2.86 times for RCS on gold, with a 9.2-fold lower variability, indicating that the homogenous and chemically inert properties of ALD-TiN may make it an ideal electrode material.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE INC , 2017. Vol. 79, 33-36 p.
Keyword [en]
Therapeutic drug monitoring, Clozapine, Redox cycling, Titanium nitride, Platinum black
National Category
Analytical Chemistry
Identifiers
URN: urn:nbn:se:kth:diva-208717DOI: 10.1016/j.elecom.2017.04.009ISI: 000402220600008ScopusID: 2-s2.0-85018580203OAI: oai:DiVA.org:kth-208717DiVA: diva2:1108388
Note

QC 2017-06-12

Available from: 2017-06-12 Created: 2017-06-12 Last updated: 2017-06-19Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
  • harvard1
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  • modern-language-association-8th-edition
  • vancouver
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More styles
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