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Poly(HEMA-co-HEMA-PFPA): Synthesis and preparation of stable micelles encapsulating imaging nanoparticles
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2017 (English)In: Journal of Colloid and Interface Science, ISSN 0021-9797, E-ISSN 1095-7103, Vol. 500, 1-8 p.Article in journal (Refereed) Published
Abstract [en]

We report the preparation of stable micelles from random copolymers of 2-hydroxyethyl methacrylate (HEMA) and perfluorophenyl azide (PFPA)-derivatized HEMA (HEMA-PFPA). The copolymers were synthesized by RAFT polymerization at room temperature under mild conditions without affecting the azide functionality. Upon addition of water to the copolymer solution in DMSO, the random copolymers self assembled into micelles even at the percentage of HEMA-PFPA as low as 4.5%. The size of the micelles can be controlled by the molecular weight and the concentration of the copolymer, and the percentage of HEMA-PFPA in the copolymer. In addition, iron oxide nanoparticles and quantum dots were successfully encapsulated into the micelles with high encapsulation efficiency (similar to 80%). These nanoparticles, which were hydrophobic and formed agglomerates in water, became fully dispersed after encapsulating into the micelles. The micelles were stable and the size remained unchanged for at least 6 months.

Place, publisher, year, edition, pages
ACADEMIC PRESS INC ELSEVIER SCIENCE , 2017. Vol. 500, 1-8 p.
Keyword [en]
Micelles, Random copolymer, HEMA, Nanoparticles, Imaging
National Category
Polymer Chemistry
Identifiers
URN: urn:nbn:se:kth:diva-208711DOI: 10.1016/j.jcis.2017.03.099ISI: 000401303000001PubMedID: 28395159ScopusID: 2-s2.0-85017133249OAI: oai:DiVA.org:kth-208711DiVA: diva2:1108468
Note

QC 2017-06-12

Available from: 2017-06-12 Created: 2017-06-12 Last updated: 2017-06-12Bibliographically approved

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