Redox-Responsive and Calcium-Dependent Switching of Glycosyldisulfide Interactions with Concanavalin A
2005 (English)In: Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, E-ISSN 1464-3405, Vol. 15, 2707-2710 p.Article in journal (Refereed) Published
Glycosyldisulfides can interact efficiently with carbohydrate-binding entities. This has been shown for a range of thiosaccharide dimers when tested for their effects against the lectin Concanavalin A using a modified quartz crystal microbalance-technique. Contrary to the thiosaccharide monomers, showing no significant binding up to 10 mM, several of the dimers showed IC50-values in the low millimolar range. Three of the glycosyldisulfides tested also displayed very high positive apparent cooperativity effects that were found to be both calcium-dependent and redox-responsive.
Place, publisher, year, edition, pages
2005. Vol. 15, 2707-2710 p.
dynamic chemistry, glycochemistry, molecular recognition, lectins, thiosaccharides, quartz crystal microbalance
IdentifiersURN: urn:nbn:se:kth:diva-6391DOI: 10.1016/j.bmcl.2005.04.024ISI: 000229665600001ScopusID: 2-s2.0-19544365923OAI: oai:DiVA.org:kth-6391DiVA: diva2:11087
QC 201009152006-11-222006-11-222010-09-15Bibliographically approved