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Redox-Responsive and Calcium-Dependent Switching of Glycosyldisulfide Interactions with Concanavalin A
KTH, School of Chemical Science and Engineering (CHE), Chemistry.
KTH, School of Chemical Science and Engineering (CHE), Chemistry.
2005 (English)In: Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, E-ISSN 1090-2120, Vol. 15, 2707-2710 p.Article in journal (Refereed) Published
Abstract [en]

Glycosyldisulfides can interact efficiently with carbohydrate-binding entities. This has been shown for a range of thiosaccharide dimers when tested for their effects against the lectin Concanavalin A using a modified quartz crystal microbalance-technique. Contrary to the thiosaccharide monomers, showing no significant binding up to 10 mM, several of the dimers showed IC50-values in the low millimolar range. Three of the glycosyldisulfides tested also displayed very high positive apparent cooperativity effects that were found to be both calcium-dependent and redox-responsive.

Place, publisher, year, edition, pages
2005. Vol. 15, 2707-2710 p.
Keyword [en]
dynamic chemistry, glycochemistry, molecular recognition, lectins, thiosaccharides, quartz crystal microbalance
National Category
Organic Chemistry
Identifiers
URN: urn:nbn:se:kth:diva-6391DOI: 10.1016/j.bmcl.2005.04.024ISI: 000229665600001Scopus ID: 2-s2.0-19544365923OAI: oai:DiVA.org:kth-6391DiVA: diva2:11087
Note
QC 20100915Available from: 2006-11-22 Created: 2006-11-22 Last updated: 2017-12-14Bibliographically approved
In thesis
1. Carbohydrate Synthesis and Study of Carbohydrate-Lectin Interactions Using QCM Biosensors and Microarray Technologies
Open this publication in new window or tab >>Carbohydrate Synthesis and Study of Carbohydrate-Lectin Interactions Using QCM Biosensors and Microarray Technologies
2006 (English)Doctoral thesis, comprehensive summary (Other scientific)
Abstract [en]

Interactions between carbohydrates and proteins are increasingly being recognized as crucial in many biological processes, such as cellular adhesion and communication. In order to investigate the interactions of carbohydrates and proteins, the development of efficient analytic technologies, as well as novel strategies for the synthesis of carbohydrates, have to be explored. To date, several methods have been exploited to analyze interactions of carbohydrates and proteins, for example, biosensors, nuclear magnetic resonance (NMR); enzyme-linked immunosorbent assays (ELISA), X-ray crystallography and array technologies. This thesis describes the development of novel strategies for the synthesis of carbohydrates, as well as new efficient strategies to Quartz Crystal Microbalance- (QCM-) biosensors and carbohydrate microarrays technologies. These methodologies have been used to probe carbohydrate-lectin-interactions for a range of plant and animal lectins.

Place, publisher, year, edition, pages
Stockholm: KTH, 2006. 106 p.
Series
Trita-IOK, ISSN 1100-7974 ; 2006:106
Keyword
Lectins; Carbohydrates; Molecular recognition; Biosensors; Quartz crystal microbalance; Carbohydrate microarrays.
National Category
Organic Chemistry
Identifiers
urn:nbn:se:kth:diva-4177 (URN)91-7178-503-5 (ISBN)
Public defence
2006-12-01, D3, Lindstedtsvägen 5, Stockholm, 10:00
Opponent
Supervisors
Note
QC 20100915Available from: 2006-11-22 Created: 2006-11-22 Last updated: 2011-09-05Bibliographically approved

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Publisher's full textScopushttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TF9-4G3KBT4-4&_user=4478132&_coverDate=06%2F02%2F2005&_alid=493490083&_rdoc=1&_fmt=summary&_orig=search&_cdi=5221&_sort=d&_docanchor=&view=c&_acct=C000034958&_version=1&_urlVersion=0&_userid=4478132&md5=97afbd5378bcef35830c01cf9eaf1928

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