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Screening and Validation of Novel Biomarkers in Osteoarticular Pathologies by Comprehensive Combination of Protein Array Technologies
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2017 (English)In: Journal of Proteome Research, ISSN 1535-3893, E-ISSN 1535-3907, Vol. 16, no 5, 1890-1899 p.Article in journal (Refereed) Published
Abstract [en]

Osteoarthritis (OA) is one of the most prevalent articular diseases. The identification of proteins closely associated with the diagnosis, progression, prognosis, and treatment response is dramatically required for this pathology. In this work, differential serum protein profiles have been identified in OA and rheumatoid arthritis (RA) by antibody arrays containing 151 antibodies against 121 antigens in a cohort of 36 samples. Then the identified differential serum protein profiles have been validated in a larger cohort of 282 samples. The overall immunoreactivity is higher in the pathological situations in comparison with the controls. Several proteins have been identified as biomarker candidates for OA and RA. Most of these biomarker candidates are proteins related to inflammatory response, lipid metabolism, or bone and extracellular matrix formation, degradation, or remodeling.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2017. Vol. 16, no 5, 1890-1899 p.
Keyword [en]
antibody arrays, serum protein profiles, osteoarthritis, rheumatoid arthritis, contact printing, noncontact printing, biomarkers
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:kth:diva-208839DOI: 10.1021/acs.jproteome.6b00980ISI: 000401044600007PubMedID: 28379711Scopus ID: 2-s2.0-85019052115OAI: oai:DiVA.org:kth-208839DiVA: diva2:1108757
Funder
Science for Life Laboratory - a national resource center for high-throughput molecular bioscience
Note

QC 20170613

Available from: 2017-06-13 Created: 2017-06-13 Last updated: 2017-06-13Bibliographically approved

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Ruiz-Romero, CristinaSjöberg, RonaldNilsson, PeterBlanco, Francisco
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Proteomics and NanobiotechnologyScience for Life Laboratory, SciLifeLab
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