Carbohydrate Synthesis and Study of Carbohydrate-Lectin Interactions Using QCM Biosensors and Microarray Technologies
2006 (English)Doctoral thesis, comprehensive summary (Other scientific)
Interactions between carbohydrates and proteins are increasingly being recognized as crucial in many biological processes, such as cellular adhesion and communication. In order to investigate the interactions of carbohydrates and proteins, the development of efficient analytic technologies, as well as novel strategies for the synthesis of carbohydrates, have to be explored. To date, several methods have been exploited to analyze interactions of carbohydrates and proteins, for example, biosensors, nuclear magnetic resonance (NMR); enzyme-linked immunosorbent assays (ELISA), X-ray crystallography and array technologies. This thesis describes the development of novel strategies for the synthesis of carbohydrates, as well as new efficient strategies to Quartz Crystal Microbalance- (QCM-) biosensors and carbohydrate microarrays technologies. These methodologies have been used to probe carbohydrate-lectin-interactions for a range of plant and animal lectins.
Place, publisher, year, edition, pages
Stockholm: KTH , 2006. , 106 p.
Trita-IOK, ISSN 1100-7974 ; 2006:106
Lectins; Carbohydrates; Molecular recognition; Biosensors; Quartz crystal microbalance; Carbohydrate microarrays.
IdentifiersURN: urn:nbn:se:kth:diva-4177ISBN: 91-7178-503-5OAI: oai:DiVA.org:kth-4177DiVA: diva2:11091
2006-12-01, D3, Lindstedtsvägen 5, Stockholm, 10:00
Pieters, Roland J., Prof.
QC 201009152006-11-222006-11-222011-09-05Bibliographically approved
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