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Targeted Photodynamic Therapy with a Folate/Sensitizer Assembly Produced from Mesoporous Silica
KTH, School of Chemical Science and Engineering (CHE), Chemistry, Surface and Corrosion Science. Nanologica AB, Sweden.
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2017 (English)In: Chemistry - A European Journal, ISSN 0947-6539, E-ISSN 1521-3765, Vol. 23, no 32, 7672-7676 p.Article in journal (Refereed) Published
Abstract [en]

A mesoporous silica material prepared by using folic acid (FA) as a template enables the effective encapsulation of meso-tetrakis(4-carboxyphenyl) porphyrin (TCPP) in its interior. Combination of steady-state and time-resolved absorption and emission spectroscopy demonstrate that FA and TCPP are released from the silica material to the aqueous phase in the form of a non-covalent assembly. This assembly does not form by simple mixing of the two components in the absence of silica, suggesting the key role of the material in the assembling process. The FA/TCPP assembly exhibits dual color fluorescence in the visible region, good photosensitization capability of singlet oxygen, and enhanced photo-induced mortality in KB cancer cells overexpressing folate receptor, if compared with the free components.

Place, publisher, year, edition, pages
Wiley-VCH Verlagsgesellschaft, 2017. Vol. 23, no 32, 7672-7676 p.
Keyword [en]
mesoporous silica, photodynamic therapy, singlet oxygen, supramolecular assembly
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:kth:diva-209292DOI: 10.1002/chem.201701432ISI: 000402799200007PubMedID: 28444786OAI: oai:DiVA.org:kth-209292DiVA: diva2:1112452
Funder
EU, FP7, Seventh Framework Programme, CYCLON-HIT 608407
Note

QC 20170620

Available from: 2017-06-20 Created: 2017-06-20 Last updated: 2017-06-20Bibliographically approved

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