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Solid nanofoams based on cellulose nanofibers and indomethacin—the effect of processing parameters and drug content on material structure
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology. KTH, School of Chemical Science and Engineering (CHE), Centres, Wallenberg Wood Science Center.
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2017 (English)In: International Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476, Vol. 526, no 1-2, 291-299 p.Article in journal (Refereed) Published
Abstract [en]

The unique colloidal properties of cellulose nanofibers (CNF), makes CNF a very interesting new excipient in pharmaceutical formulations, as CNF in combination with some poorly-soluble drugs can create nanofoams with closed cells. Previous nanofoams, created with the model drug indomethacin, demonstrated a prolonged release compared to films, owing to the tortuous diffusion path that the drug needs to take around the intact air-bubbles. However, the nanofoam was only obtained at a relatively low drug content of 21 wt% using fixed processing parameters. Herein, the effect of indomethacin content and processing parameters on the foaming properties was analysed. Results demonstrate that a certain amount of dissolved drug is needed to stabilize air-bubbles. At the same time, larger fractions of dissolved drug promote coarsening/collapse of the wet foam. The pendant drop/bubble profile tensiometry was used to verify the wet-foam stability at different pHs. The pH influenced the amount of solubilized drug and the processing-window was very narrow at high drug loadings. The results were compared to real foaming-experiments and solid state analysis of the final cellular solids. The parameters were assembled into a processing chart, highlighting the importance of the right combination of processing parameters (pH and time-point of pH adjustment) in order to successfully prepare cellular solid materials with up to 46 wt% drug loading.

Place, publisher, year, edition, pages
Elsevier, 2017. Vol. 526, no 1-2, 291-299 p.
Keyword [en]
Cellular solid material, Cellulose nanofibers, Indomethacin, Nanofoam, Poorly-soluble drugs
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:kth:diva-209536DOI: 10.1016/j.ijpharm.2017.04.041Scopus ID: 2-s2.0-85019091475OAI: oai:DiVA.org:kth-209536DiVA: diva2:1112536
Note

QC 20170620

Available from: 2017-06-20 Created: 2017-06-20 Last updated: 2017-06-20Bibliographically approved

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CiteExportLink to record
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