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Full 3-D cluster-based iterative image reconstruction tool for a small animal PET camera
KTH, School of Technology and Health (STH), Medical Engineering.ORCID iD: 0000-0001-5919-3554
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2007 (English)In: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, ISSN 0168-9002, Vol. 571, no 1-2, 219-222 p.Article in journal (Refereed) Published
Abstract [en]

Iterative reconstruction methods are commonly used to obtain images with high resolution and good signal-to-noise ratio in nuclear imaging. The aim of this work was to develop a scalable, fast, cluster based, fully 3-D iterative image reconstruction package for our small animal PET camera, the miniPET. The reconstruction package is developed to determine the 3-D radioactivity distribution from list mode type of data sets and it can also simulate noise-free projections of digital phantoms. We separated the system matrix generation and the fully 3-D iterative reconstruction process. As the detector geometry is fixed for a given camera, the system matrix describing this geometry is calculated only once and used for every image reconstruction, making the process much faster. The Poisson and the random noise sensitivity of the ML-EM iterative algorithm were studied for our small animal PET system with the help of the simulation and reconstruction tool. The reconstruction tool has also been tested with data collected by the miniPET from a line and a cylinder shaped phantom and also a rat.

Place, publisher, year, edition, pages
2007. Vol. 571, no 1-2, 219-222 p.
Keyword [en]
Medical imaging, Image reconstruction, Small animal PET
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:kth:diva-6427DOI: 10.1016/j.nima.2006.10.067ISI: 000244599100052Scopus ID: 2-s2.0-33846356997OAI: oai:DiVA.org:kth-6427DiVA: diva2:11134
Note
Accepted 2006 Published 2007 QC20100720Available from: 2006-11-27 Created: 2006-11-27 Last updated: 2011-11-07Bibliographically approved
In thesis
1. Applications of tomographic imaging in nuclear medicine
Open this publication in new window or tab >>Applications of tomographic imaging in nuclear medicine
2006 (English)Licentiate thesis, comprehensive summary (Other scientific)
Place, publisher, year, edition, pages
Stockholm: KTH, 2006. 29 p.
Series
Trita-FYS, ISSN 0280-316X ; 2006:63
National Category
Physical Sciences
Identifiers
urn:nbn:se:kth:diva-4187 (URN)
Presentation
2006-11-24, Sal FA32, AlbaNova univ. centrum, Roslagstullsbacken 21, Stockholm, 14:00 (English)
Opponent
Supervisors
Note
QC 20101125Available from: 2006-11-27 Created: 2006-11-27 Last updated: 2010-11-25Bibliographically approved
2. Software Solutions for Nuclear Imaging Systems in Cardiology, Small Animal Research and Education
Open this publication in new window or tab >>Software Solutions for Nuclear Imaging Systems in Cardiology, Small Animal Research and Education
2010 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The sensitivity for observing physiological processes makes nuclear imaging an important tool in medical diagnostics. Different types of nuclear imaging modalities, with emphasis on the software components and image reconstructions, are presented in this thesis:  the Cardiotom for myocardial heart studies at the Karolinska University Hospital, the small animal Positron Emission Tomograph (PET) scanners for research and the SPECT, PET, spiral CT and Cardiotom demonstrators for the Royal Institute of Technology medical imaging laboratory.

A modular and unified software platform has been developed for data representation, acquisition, visualization, reconstruction and presentation of the programs of the imaging devices mentioned above. The high performance 3D ML-EM and OS-EM iterative image reconstruction methods are implemented both on Cardiotom and miniPET scanners.

As a result, the in-slice resolution of the first two prototypes of the Cardiotom today is the same as the formerly used filtered back-projection, however the in-depth resolution is considerably increased. Another improvement due to the new software is the shorter time that is required for data acquisition and image reconstruction. The new electronics with the newly developed software ensure images for medical diagnosis within 10 minutes from the start ofthe examination. The first system from the standardized production of the Cardiotom cameras is in the test phase.

The performance parameters (sensitivity, spatial and energy resolution, coincidence time resolution) of the full ring mini PET camera are comparable to other small animal PETsystems.

Place, publisher, year, edition, pages
Stockholm: KTH, 2010. 75 p.
Series
Trita-STH : report, ISSN 1653-3836 ; 2010:1
National Category
Biomedical Laboratory Science/Technology
Identifiers
urn:nbn:se:kth:diva-12069 (URN)
Public defence
2010-03-19, KTH-Flemingsberg, Sal 3-221, Alfred Nobels Allé 10, Stockholm, 09:15 (English)
Opponent
Supervisors
Note
QC20100721Available from: 2010-03-02 Created: 2010-03-01 Last updated: 2010-07-21Bibliographically approved

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Valastyán, Iván

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