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Applications of tomographic imaging in nuclear medicine
KTH, School of Engineering Sciences (SCI), Physics.ORCID iD: 0000-0001-5919-3554
2006 (English)Licentiate thesis, comprehensive summary (Other scientific)
Place, publisher, year, edition, pages
Stockholm: KTH , 2006. , 29 p.
Series
Trita-FYS, ISSN 0280-316X ; 2006:63
National Category
Physical Sciences
Identifiers
URN: urn:nbn:se:kth:diva-4187OAI: oai:DiVA.org:kth-4187DiVA: diva2:11136
Presentation
2006-11-24, Sal FA32, AlbaNova univ. centrum, Roslagstullsbacken 21, Stockholm, 14:00 (English)
Opponent
Supervisors
Note
QC 20101125Available from: 2006-11-27 Created: 2006-11-27 Last updated: 2010-11-25Bibliographically approved
List of papers
1. A SPECT demonstrator - revival of a gamma camera
Open this publication in new window or tab >>A SPECT demonstrator - revival of a gamma camera
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2006 (English)In: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, ISSN 0168-9002, E-ISSN 1872-9576, Vol. 563, no 1, 274-277 p.Article in journal (Refereed) Published
Abstract [en]

A gamma camera has been updated and converted to serve as a demonstrator for educational purposes. The gantry and the camera head were the only part of the system that remained untouched. The main reason for this modernization was to increase the transparency of the gamma camera by partitioning the different logical building blocks of the system and thus providing access for inspection and improvements throughout the chain. New data acquisition and reconstruction software has been installed. By taking these measures, the camera is now used in education and also serves as a platform for tests of new hardware and software solutions. The camera is also used to demonstrate 3D (SPECT) imaging by collecting 2D projections from a rotatable cylindrical phantom. Since the camera head is not attached mechanically to the phantom, the effect of misalignment between the head and the rotation axis of the phantom can be studied. (c) 2006 Elsevier B.V. All rights reserved.

Keyword
medical imaging, gamma camera, SPECT
National Category
Medical Laboratory and Measurements Technologies
Identifiers
urn:nbn:se:kth:diva-12067 (URN)10.1016/j.nima.2006.01.089 (DOI)000238764700061 ()2-s2.0-33745064793 (Scopus ID)
Note
QC 20100721. Conference: 7th International Workshop on Radiation Imaging Detectors. Grenoble, FRANCE. JUL 04-07, 2005Available from: 2010-03-01 Created: 2010-03-01 Last updated: 2017-12-12Bibliographically approved
2. Ethernet based distributed data acquistion system for small animal PET
Open this publication in new window or tab >>Ethernet based distributed data acquistion system for small animal PET
2006 (English)In: IEEE Transactions on Nuclear Science, ISSN 0018-9499, E-ISSN 1558-1578, Vol. 53, no 4Article in journal (Refereed) Published
Abstract [en]

We report on the design of a small animal PET scanner being developed at our institutes. The existing setup is the first version of the miniPET machine consisting of four detector modules. Each detector module consists of an 8times8 LSO scintillator crystal block, a position sensitive photomultiplier, a digitizer and digital signal processing board and an Ethernet interface board. There is no hardware coincidence detection implemented in the system, coincidence is determined based on a time stamp attached to every event by a digital CFD algorithm. The algorithm is implemented in the digital signal processing board and it generates a time stamp with a coincidence resolution of 2 to 3 ns. The data acquisition System is based on Ethernet network and is highly scalable in size and performance

Identifiers
urn:nbn:se:kth:diva-6426 (URN)10.1109/RTC.2005.1547447 (DOI)2-s2.0-33751420238 (Scopus ID)
Note
QC20100720Available from: 2006-11-27 Created: 2006-11-27 Last updated: 2017-12-14Bibliographically approved
3. Full 3-D cluster-based iterative image reconstruction tool for a small animal PET camera
Open this publication in new window or tab >>Full 3-D cluster-based iterative image reconstruction tool for a small animal PET camera
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2007 (English)In: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, ISSN 0168-9002, E-ISSN 1872-9576, Vol. 571, no 1-2, 219-222 p.Article in journal (Refereed) Published
Abstract [en]

Iterative reconstruction methods are commonly used to obtain images with high resolution and good signal-to-noise ratio in nuclear imaging. The aim of this work was to develop a scalable, fast, cluster based, fully 3-D iterative image reconstruction package for our small animal PET camera, the miniPET. The reconstruction package is developed to determine the 3-D radioactivity distribution from list mode type of data sets and it can also simulate noise-free projections of digital phantoms. We separated the system matrix generation and the fully 3-D iterative reconstruction process. As the detector geometry is fixed for a given camera, the system matrix describing this geometry is calculated only once and used for every image reconstruction, making the process much faster. The Poisson and the random noise sensitivity of the ML-EM iterative algorithm were studied for our small animal PET system with the help of the simulation and reconstruction tool. The reconstruction tool has also been tested with data collected by the miniPET from a line and a cylinder shaped phantom and also a rat.

Keyword
Medical imaging, Image reconstruction, Small animal PET
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:kth:diva-6427 (URN)10.1016/j.nima.2006.10.067 (DOI)000244599100052 ()2-s2.0-33846356997 (Scopus ID)
Note
Accepted 2006 Published 2007 QC20100720Available from: 2006-11-27 Created: 2006-11-27 Last updated: 2017-12-14Bibliographically approved
4. Validation of an iterative reconstruction for a mobile tomographic gamma camera system - The Cardiotom
Open this publication in new window or tab >>Validation of an iterative reconstruction for a mobile tomographic gamma camera system - The Cardiotom
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2007 (English)In: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, ISSN 0168-9002, E-ISSN 1872-9576, Vol. 580, no 2, 1097-1100 p.Article in journal (Refereed) Published
Abstract [en]

The Cardiotom is a mobile gamma camera that uses ectomography, an alternative method of acquisition to SPECT. It is designed for early diagnosis of myocardial and cerebral infarctions in the emergency room. Ectomography is a limited view angle method, using a rotating slant hole collimator and a stationary camera head, to acquire projection images. The aim of this work was to validate a fully 3D ML-EM iterative reconstruction algorithm for the Cardiotom. Validation measurements were performed with Tc-99m point sources. Resolution in the reconstructed volume was determined in X, Y. and Z directions from the point spread functions. The results were compared with the values for the formerly used filtered back projection (FBP). The new reconstruction algorithm provides greatly improved depth resolution with respect to the FBP method previously implemented on the Cardiotom. Furthermore, for clinical examinations, images can be available for interpretation within 15 min of the injection, therefore, valuable information can be obtained without delaying treatment of the patient. (c) 2007 Elsevier B.V. All rights reserved.

Keyword
medical imaging, image reconstruction, SPECT, gamma camera
National Category
Biomedical Laboratory Science/Technology
Identifiers
urn:nbn:se:kth:diva-12059 (URN)10.1016/j.nima.2007.06.069 (DOI)000250128000056 ()2-s2.0-34548511146 (Scopus ID)
Note
QC20100720Available from: 2010-03-01 Created: 2010-03-01 Last updated: 2017-12-12Bibliographically approved

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Valastyán, Iván

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