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Spontaneous cortical activity is transiently poised close to criticality
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2017 (English)In: PloS Computational Biology, ISSN 1553-734X, E-ISSN 1553-7358, Vol. 13, no 5, e1005543Article in journal (Refereed) Published
Abstract [en]

Brain activity displays a large repertoire of dynamics across the sleep-wake cycle and even during anesthesia. It was suggested that criticality could serve as a unifying principle underlying the diversity of dynamics. This view has been supported by the observation of spontaneous bursts of cortical activity with scale-invariant sizes and durations, known as neuronal avalanches, in recordings of mesoscopic cortical signals. However, the existence of neuronal avalanches in spiking activity has been equivocal with studies reporting both its presence and absence. Here, we show that signs of criticality in spiking activity can change between synchronized and desynchronized cortical states. We analyzed the spontaneous activity in the primary visual cortex of the anesthetized cat and the awake monkey, and found that neuronal avalanches and thermodynamic indicators of criticality strongly depend on collective synchrony among neurons, LFP fluctuations, and behavioral state. We found that synchronized states are associated to criticality, large dynamical repertoire and prolonged epochs of eye closure, while desynchronized states are associated to sub-criticality, reduced dynamical repertoire, and eyes open conditions. Our results show that criticality in cortical dynamics is not stationary, but fluctuates during anesthesia and between different vigilance states.

Place, publisher, year, edition, pages
Public Library of Science , 2017. Vol. 13, no 5, e1005543
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:kth:diva-210500DOI: 10.1371/journal.pcbi.1005543ISI: 000402889500037Scopus ID: 2-s2.0-85020129400OAI: oai:DiVA.org:kth-210500DiVA: diva2:1119682
Funder
EU, FP7, Seventh Framework Programme, FP7-2010-IST-FETPI 269921EU, European Research Council, 295129EU, Horizon 2020, 720270 (HBP SGA1)
Note

QC 20170704

Available from: 2017-07-04 Created: 2017-07-04 Last updated: 2017-07-04Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
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  • ieee
  • modern-language-association-8th-edition
  • vancouver
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More styles
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  • de-DE
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