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Structure and bioactivity of the polysaccharides in medicinal plant Dendrobium huoshanense
Academia Sinica, Taiwan.ORCID iD: 0000-0002-0968-5793
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2008 (English)In: Bioorganic & Medicinal Chemistry, ISSN 0968-0896, E-ISSN 1464-3391, Vol. 16, no 11, p. 6054-68Article in journal (Refereed) Published
Abstract [en]

Detailed structures of the active polysaccharides extracted from the leaf and stem cell walls and mucilage of Dendrobium huoshanense are determined by using various techniques, including chromatographic, spectroscopic, chemical, and enzymatic methods. The mucilage polysaccharide exhibits specific functions in activating murine splenocytes to produce several cytokines including IFN-gamma, IL-10, IL-6, and IL-1alpha, as well as hematopoietic growth factors GM-CSF and G-CSF. However, the deacetylated mucilage obtained from an alkaline treatment fails to induce cytokine production. The structure and bioactivity of mucilage components are validated by further fractionation. This is the first study that provides clear evidence for the structure and activity relationship of the polysaccharide in D. huoshanense.

Place, publisher, year, edition, pages
Elsevier, 2008. Vol. 16, no 11, p. 6054-68
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Medicinal Chemistry
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URN: urn:nbn:se:kth:diva-211528DOI: 10.1016/j.bmc.2008.04.042ISI: 000256378200023PubMedID: 18467102Scopus ID: 2-s2.0-44449110574OAI: oai:DiVA.org:kth-211528DiVA, id: diva2:1129704
Note

QC 20170807

Available from: 2017-08-06 Created: 2017-08-06 Last updated: 2018-01-13Bibliographically approved

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