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Total synthesis of homogeneous variants of hirudin P6: a post-translationally modified anti-thrombotic leech-derived protein
University of Sydney, Australia.ORCID iD: 0000-0002-0968-5793
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2014 (English)In: Angewandte Chemie International Edition, ISSN 1433-7851, E-ISSN 1521-3773, Vol. 53, no 15, p. 3947-51Article in journal (Refereed) Published
Abstract [en]

Hirudin P6 is a leech-derived anti-thrombotic protein which possesses two post-translational modifications, O-glycosylation and tyrosine sulfation. In this study we report the ligation-based synthesis of a library of hirudin P6 proteins possessing homogeneous glycosylation and sulfation modifications. The nature of the modifications incorporated was shown to have a drastic effect on inhibition against both the fibrinogenolytic and amidolytic activities of thrombin and thus highlights a potential means for attenuating the biological activity of the protein.

Place, publisher, year, edition, pages
Wiley-VCH Verlagsgesellschaft, 2014. Vol. 53, no 15, p. 3947-51
Keywords [en]
glycoprotein, glycosylation, ligation, sulfation, sulfoprotein
National Category
Organic Chemistry
Identifiers
URN: urn:nbn:se:kth:diva-211521DOI: 10.1002/anie.201310777ISI: 000333634800031PubMedID: 24615823Scopus ID: 2-s2.0-84898075986OAI: oai:DiVA.org:kth-211521DiVA, id: diva2:1129705
Note

QC 20170804

Available from: 2017-08-06 Created: 2017-08-06 Last updated: 2017-08-07Bibliographically approved

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