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Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin
University of Sydney, Australia.ORCID iD: 0000-0002-0968-5793
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2012 (English)In: Chemical Communications, ISSN 1359-7345, E-ISSN 1364-548X, Vol. 48, no 10, p. 1547-9Article in journal (Refereed) Published
Abstract [en]

Synthesis of sulfated and unsulfated (glyco)peptide fragments of Hirudin P6 (a potent anticoagulant from the leech Hirudinaria manillensis) is described. The effect of O-glycosylation and tyrosine sulfation on thrombin binding and peptidolytic activity was investigated, together with the inhibition of fibrinogen cleavage.

Place, publisher, year, edition, pages
Royal Society of Chemistry, 2012. Vol. 48, no 10, p. 1547-9
Keyword [en]
Protecting-Group Strategy, Solid-Phase Synthesis, Hirudinaria-Manillensis, Sequence
National Category
Organic Chemistry Medicinal Chemistry Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:kth:diva-211525DOI: 10.1039/c1cc14773kISI: 000298989800051PubMedID: 22109100Scopus ID: 2-s2.0-84855710913OAI: oai:DiVA.org:kth-211525DiVA, id: diva2:1129710
Note

QC 20170807

Available from: 2017-08-06 Created: 2017-08-06 Last updated: 2018-01-13Bibliographically approved

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