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Numerical simulations of elastic capsules with nucleus in shear flow
KTH, School of Engineering Sciences (SCI), Mechanics. KTH, School of Engineering Sciences (SCI), Centres, Linné Flow Center, FLOW. KTH, Centres, SeRC - Swedish e-Science Research Centre.
KTH, School of Engineering Sciences (SCI), Mechanics. KTH, School of Engineering Sciences (SCI), Centres, Linné Flow Center, FLOW. KTH, Centres, SeRC - Swedish e-Science Research Centre.
KTH, School of Engineering Sciences (SCI), Mechanics. KTH, School of Engineering Sciences (SCI), Centres, Linné Flow Center, FLOW. KTH, Centres, SeRC - Swedish e-Science Research Centre.
KTH, School of Engineering Sciences (SCI), Mechanics. KTH, School of Engineering Sciences (SCI), Centres, Linné Flow Center, FLOW. KTH, Centres, SeRC - Swedish e-Science Research Centre.ORCID iD: 0000-0002-4346-4732
2017 (English)In: EUROPEAN JOURNAL OF COMPUTATIONAL MECHANICS, ISSN 1779-7179, Vol. 26, no 1-2, 131-153 p.Article in journal (Refereed) Published
Abstract [en]

The shear-induced deformation of a capsule with a stiff nucleus, a model of eukaryotic cells, is studied numerically. The membrane of the cell and of its nucleus are modelled as a thin elastic material obeying a Neo-Hookean constitutive law. The fluid-structure coupling is obtained using an immersed boundary method. The variations induced by the presence of the nucleus on the cell deformation are investigated when varying the viscosity ratio between the inner and outer fluids, the membrane elasticity and its bending stiffness. The deformation of the eukaryotic cell is smaller than that of the prokaryotic one. The reduction in deformation increases for larger values of the capillary number. The eukaryotic cell remains thicker in itsmiddle part compared to the prokaryotic one, thus making it less flexible to pass through narrow capillaries. For a viscosity ratio of 5, the deformation of the cell is smaller than in the case of uniform viscosity. In addition, for non-zero bending stiffness of the membrane, the deformation decreases and the shape is closer to an ellipsoid. Finally, we compare the results obtained modelling the nucleus as an inner stiffer membrane with those obtained using a rigid particle.

Place, publisher, year, edition, pages
Taylor & Francis, 2017. Vol. 26, no 1-2, 131-153 p.
Keyword [en]
Capsule, nucleus, shear flow, immersed boundary method
National Category
Fluid Mechanics and Acoustics
Identifiers
URN: urn:nbn:se:kth:diva-211628ISI: 000406001800009Scopus ID: 2-s2.0-85014470144OAI: oai:DiVA.org:kth-211628DiVA: diva2:1130446
Funder
EU, European Research Council, ERC-2013-CoG616186Swedish Research CouncilSwedish National Infrastructure for Computing (SNIC), SNIC 2016/10-36
Note

QC 20170809

Available from: 2017-08-09 Created: 2017-08-09 Last updated: 2017-11-29Bibliographically approved

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Banaei, Arash AlizadLoiseau, Jean-ChristopheLashgari, ImanBrandt, L.uca

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Banaei, Arash AlizadLoiseau, Jean-ChristopheLashgari, ImanBrandt, L.uca
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