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TH‐E‐217A‐01: Philips Microdose Mammography ‐ the Technology and Physics Behind the First FDA Approved Photon Counting X‐Ray Imaging System
KTH, School of Engineering Sciences (SCI), Physics, Physics of Medical Imaging.
2012 (English)In: Medical physics (Lancaster), ISSN 0094-2405, Vol. 39, no 6, p. 4017-4017Article in journal (Refereed) Published
Abstract [en]

Purpose: To validate the use of 4D‐Computed Tomography (4D‐CT) for pre‐treatment evaluation of fractional regional ventilation in patients with lung cancer by benchmarking its performance against scintigraphy V/Q imaging, the current gold‐standard. The second aim is to further corroborate the results of 4D‐CT estimation of lung aeration against the results of Pulmonary Function Testing. Methods: Scintigraphy V/Q and 4D‐CT studies were acquired in four lung cancer patients prior to treatment with radiation therapy. PFTs were acquired in 3 out of the 4 patients. 4D‐CT images were used to create 3D fractional regional ventilation maps by applying a ‘mass correction’ and subtracting the spatially matched end‐exhale and end‐inhale images. Ventilation maps were then collapsed in the anterior‐posterior dimension to create a coronal 2D projection image consistent with the scintigraphy V/Q images. The left and right lung fields were isolated on the projection image and divided into 3 sections of equal height. Summation of the signal intensity in each of the sections was carried out on the maps analogous to the analysis performed on V/Q scans and statistically compared using the Kendall's tau rank correlation. Results: The non‐parametric Kendall's tau estimate ranged between 0.87–0.95 for N=4, with corresponding p‐values ranging between 0.005–0.0002. Mean functional residual capacities (FRC) from the PFTs (N=3) versus calculated FRCs was 2.7 +/− 0.6 L and 2.4 +/− 0.7 L, and the null hypothesis could not be rejected (p = 0.61). The mean fractional regional ventilation versus the ratio of tidal‐volume/FRC was 0.24 +/− 0.11 and 0.22 +/− 0.08, and the null hypothesis could not be rejected (p=0.73). Conclusions: There was a strong correlation between 4D‐CT and scintigraphy V/Q. The similarity between the calculated and measured FRCs further validates the utility of 4D‐CT and supports its use in evaluating lung ventilation in patients with pulmonary neoplasms.

Place, publisher, year, edition, pages
American Association of Physicists in Medicine , 2012. Vol. 39, no 6, p. 4017-4017
National Category
Radiology, Nuclear Medicine and Medical Imaging
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URN: urn:nbn:se:kth:diva-213352DOI: 10.1118/1.4736386Scopus ID: 2-s2.0-85024811016OAI: oai:DiVA.org:kth-213352DiVA, id: diva2:1137042
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QC 20170830

Available from: 2017-08-30 Created: 2017-08-30 Last updated: 2017-08-30Bibliographically approved

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