Chemoenzymatic preparation of (2S,3S)- and (2R,3R)-2,3-butanediols and their esters from mixtures of d,l- and meso-diols
2001 (English)In: Tetrahedron: asymmetry, ISSN 0957-4166, E-ISSN 1362-511X, Vol. 12, no 5, 771-778 p.Article in journal (Refereed) Published
An efficient method of preparing the pure enantiomers of 2,3-butanediol front commercially available mixtures of the d,l- and meso-isomers was developed. It furnished (2S,3S)-2.3-butanediol with > 99% e.e. and a >9.5/0.5 diastereomeric ratio and (2R,3R)-2,3-butanediol in 95% e.e. and >9.5/<5 diastereomeric ratio.
Place, publisher, year, edition, pages
2001. Vol. 12, no 5, 771-778 p.
sequential kinetic resolution, 2 consecutive steps, computer-program, lipase, hydrolysis, transesterification, optimization, simulation, isomers
IdentifiersURN: urn:nbn:se:kth:diva-6643DOI: 10.1016/S0957-4166(01)00109-4ISI: 000168596200015OAI: oai:DiVA.org:kth-6643DiVA: diva2:11408
QC 201010202005-09-212005-09-212010-10-20Bibliographically approved