Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
A pathology atlas of the human cancer transcriptome
KTH, Centres, Science for Life Laboratory, SciLifeLab. KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology. Center for Biosustainability, Danish Technical University, Copenhagen, Denmark..ORCID iD: 0000-0001-8993-048X
KTH, Centres, Science for Life Laboratory, SciLifeLab.
KTH, Centres, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0002-6428-5936
KTH, Centres, Science for Life Laboratory, SciLifeLab. Department of Immunology Genetics and Pathology, Uppsala University, Uppsala, Sweden..ORCID iD: 0000-0002-0327-7377
Show others and affiliations
2017 (English)In: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 357, no 6352, p. 660-+Article in journal (Refereed) Published
Abstract [en]

Cancer is one of the leading causes of death, and there is great interest in understanding the underlying molecular mechanisms involved in the pathogenesis and progression of individual tumors. We used systems-level approaches to analyze the genome-wide transcriptome of the protein-coding genes of 17 major cancer types with respect to clinical outcome. A general pattern emerged: Shorter patient survival was associated with up-regulation of genes involved in cell growth and with down-regulation of genes involved in cellular differentiation. Using genome-scale metabolic models, we show that cancer patients have widespread metabolic heterogeneity, highlighting the need for precise and personalized medicine for cancer treatment. All data are presented in an interactive open-access database (www.proteinatlas.org/pathology) to allow genome-wide exploration of the impact of individual proteins on clinical outcomes.

Place, publisher, year, edition, pages
American Association for the Advancement of Science , 2017. Vol. 357, no 6352, p. 660-+
National Category
Medical Biotechnology
Identifiers
URN: urn:nbn:se:kth:diva-214334DOI: 10.1126/science.aan2507ISI: 000407793600028Scopus ID: 2-s2.0-85028362951OAI: oai:DiVA.org:kth-214334DiVA, id: diva2:1140860
Funder
Swedish Cancer SocietyScience for Life Laboratory - a national resource center for high-throughput molecular bioscienceKnut and Alice Wallenberg FoundationSwedish Research Council
Note

QC 20170913

Available from: 2017-09-13 Created: 2017-09-13 Last updated: 2018-10-17Bibliographically approved
In thesis
1.
The record could not be found. The reason may be that the record is no longer available or you may have typed in a wrong id in the address field.

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textScopus

Authority records BETA

Uhlén, MathiasLee, SunjaeSjöstedt, EvelinaFagerberg, LinnHober, SophiaNilsson, PeterSchwenk, Jochen M.Mardinoglu, Adil

Search in DiVA

By author/editor
Uhlén, MathiasZhang, ChengLee, SunjaeSjöstedt, EvelinaFagerberg, LinnBidkhori, GholamrezaBenfeitas, RuiArif, MuhammadLiu, ZhengtaoEdfors, FredrikSanli, Kemalvon Feilitzen, KalleOksvold, PerLundberg, EmmaHober, SophiaNilsson, PeterSchwenk, Jochen M.Mardinoglu, Adil
By organisation
Science for Life Laboratory, SciLifeLabProteomics and NanobiotechnologySchool of Biotechnology (BIO)
In the same journal
Science
Medical Biotechnology

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 611 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf