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Batch fabrication of polymer microfluidic cartridges for QCM sensor packaging by direct bonding
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.ORCID iD: 0000-0001-6443-878X
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.ORCID iD: 0000-0003-4322-6192
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
Show others and affiliations
2017 (English)In: Journal of Micromechanics and Microengineering, ISSN 0960-1317, E-ISSN 1361-6439, Vol. 27, no 12, article id 124001Article in journal (Refereed) Published
Abstract [en]

Quartz crystal microbalance (QCM) sensing is an established technique commonly used in laboratory based life-science applications. However, the relatively complex, multi-part design and multi-step fabrication and assembly of state-of-the-art QCM cartridges makes them unsuited for disposable applications such as point-of-care (PoC) diagnostics. In this work, we present the uncomplicated manufacturing of QCMs in polymer microfluidic cartridges. Our novel approach comprises two key innovations: the batch reaction injection molding of microfluidic parts; and the integration of the cartridge components by direct, unassisted bonding. We demonstrate molding of batches of 12 off-stoichiometry thiol-ene epoxy polymer (OSTE+) polymer parts in a single molding cycle using an adapted reaction injection molding process; and the direct bonding of the OSTE+ parts to other OSTE+ substrates, to printed circuit boards, and to QCMs. The microfluidic QCM OSTE+ cartridges were successfully evaluated in terms of liquid sealing as well as electrical properties, and the sensor performance characteristics are on par with those of commercially available QCM biosensor cartridge.

Place, publisher, year, edition, pages
2017. Vol. 27, no 12, article id 124001
Keywords [en]
QCM, sensor packaging, integration, bonding, polymer, off-stoichiometric thiol–ene, epoxy, OSTE+, microfluidics, reaction injection molding, RIM, batch fabrication
National Category
Nano Technology
Identifiers
URN: urn:nbn:se:kth:diva-215497DOI: 10.1088/1361-6439/aa91fdISI: 000414673600001Scopus ID: 2-s2.0-85038404178OAI: oai:DiVA.org:kth-215497DiVA, id: diva2:1148066
Funder
EU, FP7, Seventh Framework Programme
Note

QC 20171114

Available from: 2017-10-09 Created: 2017-10-09 Last updated: 2019-04-04Bibliographically approved
In thesis
1. Thiol-ene Nanostructuring
Open this publication in new window or tab >>Thiol-ene Nanostructuring
2019 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Improving the health and well-being of humankind does not only constitute

part of our moral codes, but is also enlisted as the number three goal of

the 2030 agenda for sustainable development set by the UN. Fulfilling such

objective in the regions of resource-poor settings or for age groups with more

vulnerability to infectious agents demands immediate actions. This has necessitated

novel ways of rapid and ultra-sensitive diagnostics to provide compact

and affordable systems, e.g. for an early detection of bacteria and viruses.

The fields of bio-micro/nanoelectromechanical systems (BioMEMS/NEMS)

and lab-on-a-chip (LoC) have been founded based on such demands, but

critically challenged by problems partly associated with manufacturing and

material domains and biosensing methods. The fabrication methods for the

miniaturization of features and components are often complicated and expensive,

the commonly used materials are typically not adaptable to industrial

settings, and the sensing mechanisms are sometimes not sensitive enough for

the detection of lowly-concentrated samples.

In this thesis, new methods of ultra-miniaturization, as well as conventional

cleanroom-based techniques, for nanopatterning of well-defined topographies

in off-stoichiometry thiol-ene-(epoxy) polymers are presented. In addition,

their use for several sensing applications has been demonstrated. The

first part of the thesis gives an introduction to the field of BioMEMS/NEMS.

The second part of the thesis presents a technical background about the

prevalent methods of polymer micro- and nanofabrication, implementation

of the resulting polymer structures for different sensing applications, along

with the existing challenges and shortcomings associated with state of the

art. The third part of the thesis presents e-beam nanostructuring of thiol-ene

resist, for the first time, achieving the smallest and densest features reported

in these polymer networks. The thiol-ene-based polymer also represents a

novel class of e-beam resist resulting in structures with reactive surface nature.

The fourth part of the thesis demonstrates the use of thiol-ene-epoxy

systems for nanoimprint lithography and further shows the structuring of

high-aspect-ratio and hierarchical topologies via single-step UV-NIL. The fifth

part of the thesis introduces Micro- and NanoRIM platforms for scalable and

off-cleanroom manufacturing of microfluidic devices and nanostructuring of

materials in thiol-ene (-epoxy) systems. The sixth part of the thesis exhibits

the implementation of the noted nanofabrication methods for different

BioMEMS/NEMS applications including protein nanopatterning, simultaneous

molding and surface energy patterning, ultra-sensitive digital biosensing,

and facile quartz crystal microbalance (QCM) sensor packaging.

Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology, 2019. p. 109
Series
TRITA-EECS-AVL ; 2019:32
Keywords
Nanostructuring, thiol-ene, OSTE, electron beam lithography (EBL), reaction injection molding (RIM), nanoimprint lithography (NIL), BioNEMS, QCM, digital bioassay, protein patterning, Lab-on-a-chip, polymer
National Category
Nano Technology
Identifiers
urn:nbn:se:kth:diva-235348 (URN)978-91-7873-154-1 (ISBN)
Public defence
2019-04-26, Kollegiesalen, Brinellvägen 8, KTH Royal Institute of Technolog, Stockholm, 10:00 (English)
Opponent
Supervisors
Note

QC 20190405

Available from: 2019-04-05 Created: 2019-04-04 Last updated: 2019-04-08Bibliographically approved

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