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Batch fabrication of polymer microfluidic cartridges for QCM sensor packaging by direct bonding
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.ORCID iD: 0000-0001-6443-878X
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.ORCID iD: 0000-0003-4322-6192
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
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2017 (English)In: Journal of Micromechanics and Microengineering, ISSN 0960-1317, E-ISSN 1361-6439, Vol. 27, no 12, article id 124001Article in journal (Refereed) Published
Abstract [en]

Quartz crystal microbalance (QCM) sensing is an established technique commonly used in laboratory based life-science applications. However, the relatively complex, multi-part design and multi-step fabrication and assembly of state-of-the-art QCM cartridges makes them unsuited for disposable applications such as point-of-care (PoC) diagnostics. In this work, we present the uncomplicated manufacturing of QCMs in polymer microfluidic cartridges. Our novel approach comprises two key innovations: the batch reaction injection molding of microfluidic parts; and the integration of the cartridge components by direct, unassisted bonding. We demonstrate molding of batches of 12 off-stoichiometry thiol-ene epoxy polymer (OSTE+) polymer parts in a single molding cycle using an adapted reaction injection molding process; and the direct bonding of the OSTE+ parts to other OSTE+ substrates, to printed circuit boards, and to QCMs. The microfluidic QCM OSTE+ cartridges were successfully evaluated in terms of liquid sealing as well as electrical properties, and the sensor performance characteristics are on par with those of commercially available QCM biosensor cartridge.

Place, publisher, year, edition, pages
2017. Vol. 27, no 12, article id 124001
Keywords [en]
QCM, sensor packaging, integration, bonding, polymer, off-stoichiometric thiol–ene, epoxy, OSTE+, microfluidics, reaction injection molding, RIM, batch fabrication
National Category
Nano Technology
Identifiers
URN: urn:nbn:se:kth:diva-215497DOI: 10.1088/1361-6439/aa91fdISI: 000414673600001Scopus ID: 2-s2.0-85038404178OAI: oai:DiVA.org:kth-215497DiVA, id: diva2:1148066
Funder
EU, FP7, Seventh Framework Programme
Note

QC 20171114

Available from: 2017-10-09 Created: 2017-10-09 Last updated: 2017-11-20Bibliographically approved

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Sandström, NiklasZandi Shafagh, RezaGylfason, KristinnHaraldsson, Tommyvan der Wijngaart, Wouter
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