Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Growth Description for Vessel Wall Adaptation: A Thick-Walled Mixture Model of Abdominal Aortic Aneurysm Evolution
KTH, School of Engineering Sciences (SCI), Solid Mechanics (Dept.). Insigneo Institute for in silico Medicine, University of Sheffield, Sheffield S1 3JD, UK.
KTH, School of Engineering Sciences (SCI), Solid Mechanics (Dept.).
2017 (English)In: Materials, ISSN 1996-1944, E-ISSN 1996-1944, Vol. 10, no 9, 994Article in journal (Refereed) Published
Abstract [en]

(1) Background: Vascular tissue seems to adapt towards stable homeostatic mechanical conditions, however, failure of reaching homeostasis may result in pathologies. Current vascular tissue adaptation models use many ad hoc assumptions, the implications of which are far from being fully understood; (2) Methods: The present study investigates the plausibility of different growth kinematics in modeling Abdominal Aortic Aneurysm (AAA) evolution in time. A structurally motivated constitutive description for the vessel wall is coupled to multi-constituent tissue growth descriptions; Constituent deposition preserved either the constituent's density or its volume, and Isotropic Volume Growth (IVG), in-Plane Volume Growth (PVG), in-Thickness Volume Growth (TVG) and No Volume Growth (NVG) describe the kinematics of the growing vessel wall. The sensitivity of key modeling parameters is explored, and predictions are assessed for their plausibility; (3) Results: AAA development based on TVG and NVG kinematics provided not only quantitatively, but also qualitatively different results compared to IVG and PVG kinematics. Specifically, for IVG and PVG kinematics, increasing collagen mass production accelerated AAA expansion which seems counterintuitive. In addition, TVG and NVG kinematics showed less sensitivity to the initial constituent volume fractions, than predictions based on IVG and PVG; (4) Conclusions: The choice of tissue growth kinematics is of crucial importance when modeling AAA growth. Much more interdisciplinary experimental work is required to develop and validate vascular tissue adaption models, before such models can be of any practical use.

Place, publisher, year, edition, pages
MDPI AG , 2017. Vol. 10, no 9, 994
Keyword [en]
soft tissue, mixture model, growth, volume growth, vascular adaptation, G&R, AAA
National Category
Materials Engineering
Identifiers
URN: urn:nbn:se:kth:diva-215828DOI: 10.3390/ma10090994ISI: 000411506700014Scopus ID: 2-s2.0-85028390735OAI: oai:DiVA.org:kth-215828DiVA: diva2:1149869
Note

QC 20171017

Available from: 2017-10-17 Created: 2017-10-17 Last updated: 2017-11-29Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textScopus

Authority records BETA

Gasser, T. Christian

Search in DiVA

By author/editor
Grytsan, AndriiGasser, T. Christian
By organisation
Solid Mechanics (Dept.)
In the same journal
Materials
Materials Engineering

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 13 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf