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Systemic Hypoxia Increases the Expression of DPP4 in Preadipocytes of Healthy Human Participants
KTH, School of Technology and Health (STH), Environmental Physiology. KTH, School of Technology and Health (STH), Centres, Swedish Aerospace Physiology Centre, SAPC.
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2017 (English)In: Experimental and clinical endocrinology & diabetes, ISSN 0947-7349, E-ISSN 1439-3646Article in journal (Refereed) Published
Abstract [en]

Dipeptidyl peptidase 4 (DPP4) is a transmembrane glycoprotein involved in protein degradation. Due to its action on incretins, which increase insulin secretion, DPP4 is considered a therapeutic target for type 2 diabetes. Here we have studied the role of single and combined effects of hypoxia and inactivity on the expression of DPP4 in human adipose tissue of 12 adult normal-weight males. Fat biopsies were obtained at baseline and after each of three experimental campaigns. The results revealed that in isolated human preadipocytes the expression of DPP4 was significantly increased by exposure of participants to hypoxia. Physical inactivity per se had no apparent effect on the DPP4 expression. It is concluded that DPP4 may be a marker to monitor indirectly tissue hypoxia, as occurs in obese subjects.

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Georg Thieme Verlag KG, 2017.
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Medical and Health Sciences
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URN: urn:nbn:se:kth:diva-216424DOI: 10.1055/s-0043-113451ISI: 000425527000004PubMedID: 28950392Scopus ID: 2-s2.0-85030314979OAI: oai:DiVA.org:kth-216424DiVA, id: diva2:1151132
Note

QC 20171024

Available from: 2017-10-22 Created: 2017-10-22 Last updated: 2018-03-13Bibliographically approved

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