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Safe therapeutics of murine melanoma model using a novel antineoplasic, the partially methylated mannogalactan from Pleurotus eryngii
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2017 (English)In: Carbohydrate Polymers, ISSN 0144-8617, E-ISSN 1879-1344, Vol. 178, 95-104 p.Article in journal (Refereed) Published
Abstract [en]

A heteropolysaccharide was isolated by cold aqueous extraction from edible mushroom Pleurotus eryngii ("King Oyster") basidiocarps and its biological properties were evaluated. Structural assignments were carried out using mono-and bidimensional NMR spectroscopy, monosaccharide composition, and methylation analyses. A man-nogalactan having a main chain of (1 -> 6)-linked alpha-D-galactopyranosyl and 3-O-methyl-alpha-D-galactopyranosyl residues, both partially substituted at OH-2 by beta-D-Manp (MG-Pe) single-unit was found. Biological effects of mannogalactan from P. eryngii (MG-Pe) were tested against murine melanoma cells. MG-Pe was non-cytotoxic, but reduced in vitro melanoma cells invasion. Also, 50 mg/kg MG-Pe administration to melanoma-bearing C57BL/6 mice up to 10 days decreased in 60% the tumor volume compared to control. Additionally, no changes were observed when biochemical profile, complete blood cells count (CBC), organs, and body weight were analyzed. Mg-Pe was shown to be a promising anti-melanoma molecule capable of switching melanoma cells to a non-invasive phenotype with no toxicity to melanoma-bearing mice.

Place, publisher, year, edition, pages
ELSEVIER SCI LTD , 2017. Vol. 178, 95-104 p.
Keyword [en]
Pleurotus eryngii ("King Oyster"), Mannogalactan, Chemical structure, Antitumor, Melanoma B16-F10, Non-cytotoxic
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:kth:diva-217014DOI: 10.1016/j.carbpol.2017.08.117ISI: 000413038000012Scopus ID: 2-s2.0-85029409912OAI: oai:DiVA.org:kth-217014DiVA: diva2:1154152
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QC 20171101

Available from: 2017-11-01 Created: 2017-11-01 Last updated: 2018-01-13Bibliographically approved

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Ruthes, Andrea C.

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