Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Correlations in Scattered X-Ray Laser Pulses Reveal Nanoscale Structural Features of Viruses
Show others and affiliations
2017 (English)In: Physical Review Letters, ISSN 0031-9007, E-ISSN 1079-7114, Vol. 119, no 15, article id 158102Article in journal (Refereed) Published
Abstract [en]

We use extremely bright and ultrashort pulses from an x-ray free-electron laser (XFEL) to measure correlations in x rays scattered from individual bioparticles. This allows us to go beyond the traditional crystallography and single-particle imaging approaches for structure investigations. We employ angular correlations to recover the three-dimensional (3D) structure of nanoscale viruses from x-ray diffraction data measured at the Linac Coherent Light Source. Correlations provide us with a comprehensive structural fingerprint of a 3D virus, which we use both for model-based and ab initio structure recovery. The analyses reveal a clear indication that the structure of the viruses deviates from the expected perfect icosahedral symmetry. Our results anticipate exciting opportunities for XFEL studies of the structure and dynamics of nanoscale objects by means of angular correlations.

Place, publisher, year, edition, pages
American Physical Society, 2017. Vol. 119, no 15, article id 158102
Keywords [en]
Free-Electron Laser, Diffraction Data, Angular-Correlations, Atomic-Structure, Image-Formation, Symmetries, Particles, Protein, Classification, Reconstruction
National Category
Atom and Molecular Physics and Optics
Identifiers
URN: urn:nbn:se:kth:diva-217037DOI: 10.1103/PhysRevLett.119.158102ISI: 000412840600011Scopus ID: 2-s2.0-85031315313OAI: oai:DiVA.org:kth-217037DiVA, id: diva2:1160087
Funder
Swedish Research CouncilKnut and Alice Wallenberg FoundationEU, European Research CouncilThe Swedish Foundation for International Cooperation in Research and Higher Education (STINT)Swedish Foundation for Strategic Research
Note

QC 20171124

Available from: 2017-11-24 Created: 2017-11-24 Last updated: 2017-11-30Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textScopus

Authority records BETA

Sellberg, Jonas A.

Search in DiVA

By author/editor
Sellberg, Jonas A.
By organisation
Biomedical and X-ray Physics
In the same journal
Physical Review Letters
Atom and Molecular Physics and Optics

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 17 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf