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Aorta
KTH, School of Engineering Sciences (SCI), Solid Mechanics (Dept.).
2017 (English)In: Biomechanics of Living Organs: Hyperelastic Constitutive Laws for Finite Element Modeling, Elsevier, 2017, p. 169-191Chapter in book (Refereed)
Abstract [en]

The aorta is a dynamic structure that is able to maintain conditions for optimal mechanical operation through the continuous turnover of its internal structure. The aorta's properties are critical to the entire cardiovascular system, and the study of its biomechanics may help us to better understand the role of tissue stress and strain in aortic aging and pathology, help to optimize medical devices, and improve therapeutic and diagnostic methods that are currently used in clinics. The present chapter reviews aortic wall histology and morphology in relation to its key mechanical properties. Specifically, the biomechanical role of cells (endothelial cells, smooth muscle cells, fibroblasts, etc.), as well as the extracellular matrix components (elastin, collagen, proteoglycans, water, etc.), will be discussed. Then this information is related to reported constitutive descriptions for aortic tissues. The focus is on histo-mechanical approaches and modeling frames, related to hyperelasticity as well as a superposition of fiber contributions according to a general theory of fibrous connective tissue. Concluding remarks relate to open problems in aorta biomechanics, such as uncertainty and variability of input information. Remarks are also made on the admissible degree of complexity in aortic simulations, in the context of such uncertainties.

Place, publisher, year, edition, pages
Elsevier, 2017. p. 169-191
Keyword [en]
Aorta, Cells, Collagen, Constitutive modeling, ECM, Elastin, Histology, Micromechanics, Strain energy function
National Category
Other Medical Engineering
Identifiers
URN: urn:nbn:se:kth:diva-218485DOI: 10.1016/B978-0-12-804009-6.00008-0Scopus ID: 2-s2.0-85032490613ISBN: 9780128040607 ISBN: 9780128040096 OAI: oai:DiVA.org:kth-218485DiVA, id: diva2:1161085
Note

QC 20171129

Available from: 2017-11-29 Created: 2017-11-29 Last updated: 2017-11-29Bibliographically approved

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CiteExportLink to record
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  • apa
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  • nn-NB
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  • Other locale
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