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The human protein atlas: A spatial map of the human proteome
KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology. KTH, Centres, Science for Life Laboratory, SciLifeLab. (Cell Profiling)ORCID iD: 0000-0002-6107-1465
2018 (English)In: Protein Science, ISSN 0961-8368, E-ISSN 1469-896X, Vol. 27, no 1, 233-244 p.Article in journal (Refereed) Published
Abstract [en]

The correct spatial distribution of proteins is vital for their function and often mis-localization or ectopic expression leads to diseases. For more than a decade, the Human Protein Atlas (HPA) has constituted a valuable tool for researchers studying protein localization and expression in human tissues and cells. The centerpiece of the HPA is its unique antibody collection for mapping the entire human proteome by immunohistochemistry and immunocytochemistry. By these approaches, more than 10 million images showing protein expression patterns at a single-cell level were generated and are publicly available at www.proteinatlas.org. The antibody-based approach is combined with transcriptomics data for an overview of global expression profiles. The present article comprehensively describes the HPA database functions and how users can utilize it for their own research as well as discusses the future path of spatial proteomics.

Place, publisher, year, edition, pages
Wiley , 2018. Vol. 27, no 1, 233-244 p.
Keyword [en]
spatial proteomics, transcriptomics, antibodies, immunohistochemistry, immunofluorescence, single-cell, protein expression
National Category
Cell Biology
Identifiers
URN: urn:nbn:se:kth:diva-218698DOI: 10.1002/pro.3307ISI: 000418254300024PubMedID: 28940711Scopus ID: 2-s2.0-85039049799OAI: oai:DiVA.org:kth-218698DiVA: diva2:1161438
Funder
Knut and Alice Wallenberg FoundationScience for Life Laboratory - a national resource center for high-throughput molecular bioscience
Note

QC 20171130

Available from: 2017-11-30 Created: 2017-11-30 Last updated: 2018-01-11Bibliographically approved

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