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Mapping the synthesis and the impact of low molecular weight PLGA-g-PEG on sol–gel properties to design hierarchical porous scaffolds
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology. (Polymer technology)
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology. (Polymer technology)
2014 (English)In: Journal of polymer research, ISSN 1022-9760, E-ISSN 1572-8935, Vol. 21, no 1, p. 1-11Article in journal (Refereed) Published
Abstract [en]

Bone morphogenetic protein 2 (BMP-2)-function- alized poly(L-lactide-co-ε-caprolactone) (PLCL) porous scaf- folds have shown promising results in bone tissue regenera- tion studies. It is believed that even better results are achieved by hierarchical porous scaffolds and a designed sequential release of growth factors. We therefore synthesized (L- lactide-co-glycolide)-g-poly(ethylene glycol) (PLGA-g- PEG) oligomers which could be injected into PLCL porous scaffolds. They were synthesized by ring-opening polymeri- zation and carefully characterized by nuclear magnetic reso- nance spectroscopy (NMR), matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF- MS), and size exclusion chromatography (SEC). The sol–gel transition temperature, pH, and functional life were deter- mined and correlated with the molecular structure of PLGA- g-PEG. We found that low molecular weight PLGA-g-PEG was obtained and poly(L-lactide-co-glycolide-co-poly(ethyl- ene glycol) methyl ether) (PLGA-MPEG) appeared to con- tribute to gelation. It was possible to design a system that formed a hydrogelwithin 1min at 37 °Cwith a pHbetween 6 and 7 and with a functional life of around 1 month. These low molecular weight thermosensitive PLGA-g-PEG oligomers, which can be injected into PLCL scaffolds, appear promising for bone tissue engineering applications.

Place, publisher, year, edition, pages
Springer Science+Business Media B.V., 2014. Vol. 21, no 1, p. 1-11
Keyword [en]
Thermosensitive gel, PLGA-g-PEG, Porous scaffolds, Tissue engineering, Degradable polymers
National Category
Polymer Technologies
Research subject
Chemical Engineering
Identifiers
URN: urn:nbn:se:kth:diva-219570DOI: 10.1007/s10965-013-0337-8ISI: 000328848400001Scopus ID: 2-s2.0-84890528028OAI: oai:DiVA.org:kth-219570DiVA, id: diva2:1163691
Note

QC 20171211

Available from: 2017-12-07 Created: 2017-12-07 Last updated: 2017-12-11Bibliographically approved
In thesis
1. Synthesis of degradable aliphatic polyesters: strategies to tailor the polymer microstructure
Open this publication in new window or tab >>Synthesis of degradable aliphatic polyesters: strategies to tailor the polymer microstructure
2018 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Key factors for successful tissue engineering are the synthesis and design of the scaffold materials. Aliphatic polyesters have been studied and often used as scaffold materials for tissue engineering. However, their lack of biological cues and degradation under high-temperature processing (e.g., 3D printing) are a limitation. In this thesis, different synthesis strategies are presented which has the potential to improve the performance of aliphatic polyesters as scaffolds for tissue regeneration.

To stimulate interactions between exogenous materials and the surrounding tissue, two different strategies were applied. Either, by designing a two component system in which the different degradation profiles of the polymers allow for sequential release of growth factors. Or, by peptide functionalization of an aliphatic polyester chain using template-assisted chemo-enzymatic synthesis. The results from the studies were successful. A hierarchical system was obtained in which the poly(L-lactide-co-glycolide)-graft-poly(ethylene glycol) methyl ether (PLGA-g-MPEG), hydroxyapatite solution formed a gel around and within the pores of the poly(L-lactide-co-ε-caprolactone) scaffold at 37 ºC, within 1 min, that was stable for 3 weeks. The peptide functionalization was also successful where an aliphatic polyester of L-lactide was functionalized with different oligopeptides using a grafter (ethyl hept-6-enoylalaninate) and chemo-enzymatic synthesis.

The thermal properties of poly(L-lactide-co-hydroxybutyrate) were tailored (by modification of the microstructure) to potentially improve the processability of the aliphatic polyester.  The results showed that the yttrium salan catalyst was the most successful, yielding high molecular weight copolymers in shorter time. They also showed that the Tg could be tailored by varying the amount of rac-β-butyrolactone in the copolymer to better suit thermal processing techniques, such as 3D printing.

Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology, 2018. p. 78
Series
TRITA-CHE-Report, ISSN 1654-1081 ; 2017:35
Keyword
Polymer synthesis, enzymatic synthesis, degradable polyesters, peptides, scaffolds
National Category
Polymer Technologies
Research subject
Chemical Engineering
Identifiers
urn:nbn:se:kth:diva-219550 (URN)978-91-7729-615-7 (ISBN)
Public defence
2018-01-15, F3, Lindstedtsvägen 26, Stockholm, 09:00 (English)
Opponent
Supervisors
Funder
Swedish Research Council, 2013-3764
Note

QC 20171207

Available from: 2017-12-07 Created: 2017-12-07 Last updated: 2017-12-07Bibliographically approved

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